ReviewJournal of medicinal chemistry2025
Cheap, Fast, Safe, Sustainable, and Positively Irresistible: The Future of Cationic Amphiphilic Disinfectant Development.
Review in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Detergent Conjugation Decouples Chlorpromazine Solubility from Antibacterial Activity against Bacteria Relevant for Gut Microbiota.Bioconjugate chemistry · 2026Article
- Water-Soluble Ammonium BODIPYs: Synthesis, Photophysics, Photogelation, and Antimicrobial Activity.Chemistry, an Asian journal · 2026Article
- Triscationic bolaamphiphilic QACs - optimizing antibacterial therapeutic indices.Bioorganic & medicinal chemistry letters · 2026Article
- Discovery of guanidinium salt incorporating cinnamic acid skeleton as new antibacterial agents against Gram-positive bacteria.Frontiers in microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Disinfectants represent a crucial tool in killing infectious diseases and play a major role in protecting susceptible communities (hospitals and nursing homes). Inspired by nature, over the past 100 years, scientists have sought to recreate simplified antimicrobial peptides (AMPs) to serve these purposes. Quaternary ammonium compounds (QACs) have been mainstays in the industry, with benzalkonium chloride and didecyldimethylammonium chloride representing everyday disinfection agents. Through exhaustive investigations into alternative QAC structures, we have observed a "floor" in activity, with minimum inhibitory concentration (MIC) values of approximately 0.5 μM and no lower. Interestingly, the same value arises when one calculates the theoretical maximum in activity when considering the mechanism of action, aligning with the previously reported maximum inhibitory efficacy of AMPs. Herein, we encourage that the future development of novel disinfectants instead focus on five specific design elements: cost, time-kill, toxicity, sustainability, and resistance susceptibility.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.