ReviewThe Journal of biological chemistry2025
Viral interference of nucleocytoplasmic transport.
Review in The Journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Viruses have evolved diverse strategies to exploit the compartmentalized architecture of eukaryotic cells, particularly by targeting the nuclear envelope (NE) and its associated nuclear pore complexes (NPCs). The NE, composed of a double-membrane lipid bilayer, NPCs, and the nuclear lamina, establishes a physical barrier that protects genetic material in the nucleus from harmful cytosolic agents while enabling the spatial segregation of transcription and translation. This compartmentalization allows eukaryotic cells to tightly regulate gene expression, a process that requires the bidirectional shuttling of macromolecules such as transcription factors and messenger ribonucleoprotein particles across the NE. The NPC is the sole gateway to the nucleus and is essential for protein biogenesis, metabolic homeostasis, and cell survival. In this review, we examine how viruses remodel NPC architecture, hijack nucleocytoplasmic transport, and disable host innate immune responses to enhance viral replication.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.