ArticleLearning & memory (Cold Spring Harbor, N.Y.)
Maintenance of memory by negative feedback of synaptic protein elimination: modeling KIBRA-PKMζ dynamics in LTP.
Article in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Article
- Oligomer logic of memory molecules.Molecular brain · 2026Review
- PKMζ-KIBRA interactions, molecular turnover, and memory.Molecular brain · 2026Article
- PKMζ-KIBRA interactions, molecular turnover, and memory.bioRxiv : the preprint server for biology · 2026Article
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6 authors.
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Abstract
Long-term activity-dependent modifications of synaptic strength are a cellular substrate of learning and memory, but how long-lasting memory could be based on synaptic proteins that rapidly degrade and diffuse is unknown. Most current theories depend on molecular positive-feedback loops. Recent experiments, however, reveal that interactions between kidney brain protein (KIBRA) and PKMζ downregulate the proteins' degradation and maintains late-phase long-term synaptic plasticity (LTP) and long-term memory, motivating an alternative model based on negative feedback at the level of protein elimination. Here we compare positive- and negative-feedback models generally and explore biophysical models based specifically on KIBRA-PKMζ interaction. The biophysical theory predicts LTP/memory maintenance by complexes of cooperative KIBRA-PKMζ heteromers.
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