Evidence map›Paper›PMID 41102140›Full record

ArticleNature communications2025

Virus-inspired lipopeptide-derived nucleic acid delivery to cartilage for osteoarthritis therapy.

Yu Fu, Yulan Huang, Yunjiao Wang, Zhenlan Fu, Wenyun Cai, Lu Wang, Yuchun Wu, Xing Zhou, Zhongyi Ma, Zhigang Xu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. What's next for osteoarthritis gene therapy?Frontiers in bioengineering and biotechnology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yu Fu *Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China.
Yulan Huang *Medical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China.
Yunjiao Wang *Department of Orthopaedic Surgery, Sports Medicine Center, Center for Joint Surgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, PR China.ORCID http://orcid.org/0000-0003-1108-7079
Zhenlan FuDepartment of Orthopaedic Surgery, Sports Medicine Center, Center for Joint Surgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, PR China.
Wenyun CaiMedical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China.
Lu WangMedical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China.
Yuchun WuMedical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China.
Xing ZhouCenter for Nanomedicine and Gene Therapy, School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, PR China.
Zhongyi MaMedical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China.
Zhigang XuSchool of Materials and Energy, Southwest University, Chongqing, PR China.ORCID http://orcid.org/0000-0003-1805-5061
Yaqin TangCenter for Nanomedicine and Gene Therapy, School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, PR China.
Jing XieCenter for Nanomedicine and Gene Therapy, School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, PR China.
Jiayun JiangInstitute of Hepatobiliary Surgery, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, PR China.
Robert J LeeDivision of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH, USA. lee.1339@osu.edu.
Chong LiMedical Research Institute, College of Pharmaceutical Sciences, Southwest University, Chongqing, PR China. chongli2009@gmail.com.

Funding

National Natural Science Foundation of China (National Science Foundation of China) No.22307012National Natural Science Foundation of China (National Science Foundation of China) No.82204281
6 · The paper itself

Abstract

Cartilage-targeted gene therapy is promising for osteoarthritis (OA) treatment, though its potency critically depends on the effectiveness of delivery vectors. Here, we modularly develop a series of non-pathogenic, virus-inspired lipopeptide-based nanoparticles (VPN) tailored to deliver nucleic acids to cartilage. The cationic moiety of lipopeptide with variable arginine and histidine residues is the key functional component, and screened by in vitro performance. The optimized VPN-2 with a moiety of -[(R)

Indexed as

Cartilage, ArticularGenetic TherapyLipopeptidesNucleic AcidsOsteoarthritisAnimalsGene Transfer TechniquesHumansMaleMiceMice, Inbred C57BLNanoparticlesLipopeptidesNucleic Acids

Identifiers

PMID41102140
PMCPMC12533185

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.