ArticlePediatric research2026
Children born small-for-gestational-age exhibit normal body fat but elevated hs-CRP and hepatocellular lipid content.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Circulating Adipsin as a Biomarker of Liver Fat Content in Prepubertal Children Born Small-for-Gestational-Age.International journal of molecular sciences · 2026Article
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesBeing born small-for-gestational-age (SGA), is associated with an increased risk of cardiometabolic disease in adulthood. We studied the influence of birth size on hepatocellular lipid (HCL) concentrations in prepubertal children.
methodsA total of 195 prepubertal Caucasian children (4.4-9.7 years) were studied in three cohorts. Twenty-one children were born small-for-gestational-age (SGA), 132 were appropriate-for-gestational-age (AGA), and 42 were large-for-gestational-age (LGA). The outcomes were body fat by dual-energy X-ray absorptiometry (DXA), liver fat MRI and MR spectroscopy (MRS), anthropometric measurements at examination, and biochemical markers of metabolism and inflammation.
resultsMRS revealed higher HCL in SGA children, as determined from the methylene (-CH
conclusionsOur study shows a link between SGA status, elevated hs-CRP, and elevated MRS-detectable HCL. MRS may thus be important in identifying prepubertal children at risk for metabolic sequelae. IMPACT: Prepubertal children born small-for-gestational-age (SGA), although still shorter and leaner than their peers, exhibit elevated liver triglyceride concentrations on proton MR spectroscopy associated with elevated hs-CRP levels. Elevated hs-CRP and liver triglyceride concentrations can be early indicators of pathological metabolic changes associated with later cardiometabolic abnormalities.
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