ArticleEuropean journal of applied physiology2026
Effect of an acute bout of endurance eccentric exercise on exerkines production in healthy males.
Article in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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7 authors.
Funding
Abstract
purposeStrength-related exerkines may be promoted in response to exercise imposing high mechanical stress on the skeletal muscles. For a constant velocity, the inclination of the slope during downhill exercise influences the total mechanical load. The aim of the study was to compare exerkines release following two prolonged decline walking (-10% and -20%) exercise session.
methodsTwelve moderately active healthy men (age: 23.3 ± 3.6 years; mass: 70.0 ± 4.5 kg; height: 177.2 ± 2.9 cm; body fat: 13.1 ± 3.2%) performed two 45-min downhill treadmill exercises at -10% (DOWN10) and -20% (DOWN20) slopes at the same pace (6 km.h
resultsHeart rate and muscle oxygenation were respectively greater and lower during DOWN20 exercise than DOWN10. Myostatin (MSTN; DOWN10 p ≤ 0.01 and DOWN20 p ≤ 0.05) and interleukine-6 (DOWN10 and DOWN20 p ≤ 0.001) levels increased 1 h-post exercise in both conditions while no difference was found for decorin, follistatin and the growth differentiation factor-15 levels. No difference on exerkines release was evidenced between - 10% and - 20% treadmill slope but a significant condition effect between DOWN20 and DOWN10 was observed for DCN (p ≤ 0.05).
conclusionA 45-min downhill walking exercise at a - 10% slope represents a valid strategy to stimulate the cardiovascular and muscular functions, as inferred from the increase in MSTN and IL-6 exerkines levels, and the use of a steepest slope protocol is no a prerequisite to elicit greater responses.
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