Evidence map›Paper›PMID 41102498›Full record

ReviewNature human behaviour2025

The nature of the relation between mental well-being and ill-being.

Christian K Tamnes, Mona Bekkhus, Maja Eilertsen, Ragnhild B Nes, Monica Beer Prydz, Eivind Ystrom, Eira R Aksnes, Synøve N Andersen, Helga Ask, Ziada Ayorech and 53 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature human behaviour, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

63 authors.

Christian K TamnesPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway. c.k.tamnes@psykologi.uio.no.ORCID http://orcid.org/0000-0002-9191-6764
Mona BekkhusPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Maja EilertsenPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Ragnhild B NesPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Monica Beer PrydzPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Eivind YstromPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0003-4390-6171
Eira R AksnesPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Synøve N AndersenPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Helga AskPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0003-0149-5319
Ziada AyorechPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-8372-421X
Tina BaierDepartment of Sociology and Human Geography, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-8137-7800
Dani BeckPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-0974-9304
Eirik Jerven BergerPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Ludvig D BjørndalPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-9773-8287
Olga D BoerPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Marieke G N BosDevelopmental and Educational Psychology Unit, Institute of Psychology, Leiden University, Leiden, the Netherlands.
Avshalom CaspiPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0003-0082-4600
Rosa CheesmanPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-6543-0402
Razieh ChegeniPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Laura Cortés-GarcíaPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Perline A DemangePROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-7061-8354
Joakim C EbeltoftPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0009-0003-4821-0533
Maud EdvollPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Nikolai Haahjem EftedalPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0009-0006-1328-9861
Espen Moen EilertsenPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0003-3444-4251
Yuan FangPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Lia FerschmannPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Sam FluitPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-0102-5096
Siri H FolstadPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Eivor FredriksenDepartment of Psychology, University of Oslo, Oslo, Norway.
Liridona GashiPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Kristin GustavsonDivision of Public Health and Prevention, Norwegian Institute of Public Health, Oslo, Norway.
Thomas HansenPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Live S HofgaardPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Valerie KarlPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Michal KozákPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-5799-9922
Kristian G KrogshusPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0009-0000-4372-0778
Jinrui LiuPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0009-0005-8733-1826
Torkild H LyngstadDepartment of Sociology and Human Geography, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-7830-9305
Niamh MacSweeneyPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Hermine H M MaesVirginia Institute for Psychiatric and Behavioral Genetics, Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Lilian MayerhoferPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Tom A McAdamsPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-6825-3499
Terrie E MoffittPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-8589-6760
Nasimeh NaseriPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0009-0007-6858-3993
Thomas S NilsenDivision of Public Health and Prevention, Norwegian Institute of Public Health, Oslo, Norway.
Linn B NorbomPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Egil NygaardPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-8865-4265
Aurora OftedalDivision of Public Health and Prevention, Norwegian Institute of Public Health, Oslo, Norway.
Willy PedersenDepartment of Sociology and Human Geography, University of Oslo, Oslo, Norway.
Qi QinPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0009-0001-4241-0724
Rubén Rodríguez-CanoPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Vegard SkirbekkDepartment of Psychology, University of Oslo, Oslo, Norway.
Dinka SmajlagicPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Ole Martin SolbergPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Anneli D TandbergPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Irene J E TeulingsPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Fartein Ask TorvikPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Stella TsotsiPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-2010-0709
Vidar S UlsetPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Emily G ViraPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Espen RøysambPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-5133-7170
Tilmann von SoestPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-5576-2059

Funding

Science CoreP2CHD065563 · NICHD · DUKE UNIVERSITY · PI Giovanna M Merli · 2015 to 2026
$5.7M
Using a Genetic Approach to Understand Factors Influencing Resistance to Substance UseR01DA054313 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI HERMINE H MAES, Elizabeth Chin Prom-Wormley · 2022 to 2026
$2.6M
NICHD NIH HHS P2C HD065563NIDA NIH HHS R01 DA054313
6 · The paper itself

Abstract

Research on mental health has traditionally separated the study of ill-being, including clinically defined mental and behavioural disorders and subthreshold problems, from the study of well-being, which encompasses factors such as life satisfaction and positive affect. Although previous reviews of studies primarily using self-report scales indicate that ill-being and well-being are distinct yet interconnected constructs, a deeper examination of their relationship is lacking. In this Perspective, we synthesize genetic, biological, developmental, psychosocial, societal, cultural and clinical research on ill-being and well-being. Our review reveals substantial genetic overlap and similar biological underpinnings for ill-being and well-being. By contrast, environmental factors and societal changes often exert divergent influences. We propose a differentiated multidisciplinary framework in which the shared and unique determinants, predictors, mechanisms and consequences of mental ill-being and well-being vary across levels of analysis, offering a more nuanced understanding of the interconnections.

Indexed as

Mental DisordersMental HealthPersonal SatisfactionHumans

Identifiers

PMID41102498
PMCPMC13109989

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.