ArticleBMC pregnancy and childbirth2025
Comparative metabolomic profiling reveals distinct metabolic signatures in amniotic fluid and umbilical cord blood between advanced and young maternal age pregnancies.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundGiven the heightened risk of complications during pregnancy in women of advanced maternal age (AMA), it is crucial to understand the metabolites in amniotic fluid and umbilical cord blood in this demographic.
methodsWe analyzed the metabolites in amniotic fluid from 60 women, divided into two groups: the AMA group (aged 35 or above, n = 29), and the control group (aged below 35, n = 31). We then conducted a follow-up analysis on the metabolites of umbilical cord blood from a sample of 19 women (9 from the AMA group, and 10 from the control group).
resultsIn total, we identified 96 differential metabolites in the amniotic fluid and 146 in the cord blood between the two groups. The significant changes in the metabolites of the amniotic fluid mainly involved sphingolipid metabolism, steroid hormone biosynthesis, and cholesterol metabolism. Conversely, the preliminary significant changes in cord blood metabolites were mainly linked to metabolism of arginine and proline, degradation of valine, leucine, and isoleucine, fatty acid metabolism, alanine, aspartate and glutamate metabolism, and the biosynthesis of unsaturated fatty acids. Further analysis revealed a significant upregulation of lysophosphatidylcholine (LPC), phosphatidylcholine (PC), and taurodeoxycholic acid in the amniotic fluid. In the cord blood, various forms of lysophosphatidic acid (LPA), sphingomyelin (SM), phosphatidylglycerol (PG), LPC, and PC were found preliminarily to be either upregulated or downregulated.
conclusionOur results preliminarily showed that the metabolites of amniotic fluid and cord blood in AMA women differed significantly from the control group. These findings provide crucial insights for future research to explore the role of metabolomics in adverse pregnancy outcomes in AMA women.
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