ArticleBMC complementary medicine and therapies2025
Promising anti-cervical cancer efficacy and phytochemical analysis of Vitex doniana Sweet (Verbenaceae) leaf extracts: an in vitro investigation with molecular mechanisms of action.
Article in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Synthesis and Assessment of the Enantioselectivity in Antitumor Activity of a Library of Novel Chiral Flavone Derivatives.ChemMedChem · 2026Article
- Vernodalin andBiomedicines · 2026Article
- Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions.MedComm · 2026Review
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4 authors.
Funding
Abstract
backgroundThe exploration of natural sources for novel anticancer agents has garnered significant attention in recent years, driven by the need for effective and safe anticancer medications, considering the escalating global burden of cervical cancer. Vitex doniana Sweet (Verbenaceae), a plant with diverse traditional medicinal uses, especially in Africa, has shown promise in this regard due to its rich phytochemical composition.
methodsThis study investigated the cytotoxic and antiproliferative effects of V. doniana extracts on normal mammalian (Vero-CCL-81) and cervical cancer (HeLa) cells, including cancer-associated gene expression profiles, according to standard procedures. Phytochemical analysis was performed using gas chromatography-mass spectrometry (GC-MS).
resultsThe findings revealed significant (P < 0.0001) concentration-dependent increases in cytotoxicity and inhibition of cancer cell proliferation, by the aqueous, methanolic, ethyl acetate, and dichloromethane leaf extracts of V. doniana. Notably, differential cytotoxicity profiles were observed among different extracts. The median cytotoxic concentrations (CC
conclusionThese findings provide valuable insights into the potential and molecular mechanisms underlying the anti-cervical cancer effects of V. doniana extracts, their attributable phytocompounds, and highlight their putative value as sources of lead compounds for the development of novel anticancer drugs.
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