Trial reportScandinavian journal of medicine & science in sports2025
Effects of Blood-Flow Restricted Resistance Exercise Versus Neuromuscular Exercise on Self-Perceived Knee Pain, Function, Quality of Life, and Objective Measures of Functional Performance and Pain Sensitization in Adults With Knee Osteoarthritis-A Randomized Controlled Trial.
Trial report in Scandinavian journal of medicine & science in sports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of blood flow restriction exercise interventions on patellofemoral pain syndrome: a systematic review and meta-analysis.Frontiers in physiology · 2026Pooled it
- Effects of Blood-Flow Restricted Resistance Exercise Versus Neuromuscular Exercise on Self-Perceived Knee Pain, Function, Quality of Life, and Objective Measures of Functional Performance and Pain Sensitization in Adults With Knee Osteoarthritis-A Randomized Controlled Trial.Scandinavian journal of medicine & science in sports · 2025Trial
- Absence of Evidence Is Not Evidence of Absence in Head-to-Head Exercise Intervention Studies.Scandinavian journal of medicine & science in sports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Standard rehabilitation for knee osteoarthritis (knee-OA) combines patient education and neuromuscular exercises (NEMEX). Heavy-load resistance training (HLRT) has shown positive effects on pain, functionality, and muscle mass, but can be painful with knee-OA. Low-load blood-flow restricted resistance exercise (BFR-RE) has shown comparable effects to HLRT without promoting exercise-induced pain. Therefore, the present study examined the effect of BFR-RE vs. NEMEX on self-perceived knee pain, functional performance, and pain sensitization in knee-OA individuals. Ninety-six participants (age 56.7 ± 7.6; 49 females, 47 males) with symptomatic knee-OA were randomized to 12 weeks biweekly BFR-RE or NEMEX. BFR-RE was performed at 60%-80% of total arterial occlusion pressure. Control participants completed a 12-week NEMEX program. Both groups also attended patient education. Primary outcome: Change in the Knee injury and Osteoarthritis Outcome Score (KOOS) pain subscale from baseline to 12 weeks. Secondary outcomes: Remaining KOOS subscales, Oxford Knee Score (OKS), 30-s sit-to-stand (STS), STS power, 4 × 10 m fast-paced walking (4 × 10 m-FWT), stair climb test (SCT), spreading and local pain sensitization measured as pressure pain thresholds (PPT). No significant between-group difference in the change in KOOS-Pain was observed (+6.4 points, 95% CI = -1.0-13.7, effect size (ES) = 0.35, p = 0.07) or the remaining KOOS subscales and OKS (ES = 0.05-0.20, p > 0.05). BFR-RE demonstrated greater improvements than NEMEX for all functional outcomes (STS, STS power, 4 × 10 m FWT, SCT) (ES = 0.89-1.56, p < 0.01) and spreading sensitization (ES = 0.43-0.55, p < 0.05). BFR-RE and NEMEX were equally effective in reducing knee pain, while BFR-RE achieved greater statistical gains in functional performance and improved spreading sensitization in persons with moderate knee-OA. The enhanced improvements with BFR-RE compared to NEMEX represent novel insights that should be considered in future treatments of knee-OA.
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Registered trials
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