Evidence map›Paper›PMID 41103249›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Pharmacological Microglial Inhibition Remodels the Scar Microenvironment to Support Reticulospinal Circuit Reconstruction After Spinal Cord Injury.

Run Li, Hongyuan Xing, Yifan Shen, Meng Chen, Bowen Lyu, Xiaofeng Yang, Li Sun, Chao Jiang, Jianyu Lv, Xin Ding and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Run LiDepartment of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Hongyuan XingDepartment of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Yifan ShenDepartment of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Meng ChenM.S.E, Johns Hopkins University, 3400 North Charles Street, Hopkins, MD, 21218, USA.
Bowen LyuDepartment of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Xiaofeng YangSoochow Key Laboratory of Prevention and Treatment of Child Brain injury, Children's Hospital of Soochow University, Suzhou, 215025, China.
Li SunSoochow Key Laboratory of Prevention and Treatment of Child Brain injury, Children's Hospital of Soochow University, Suzhou, 215025, China.
Chao JiangDepartment of Orthopedics, Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University, Taizhou, 317000, China.
Jianyu LvDepartment of Gastroenterology, The Second Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310005, China.
Xin DingDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, 215000, China.
Zhongyang GaoDepartment of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Yue WangDepartment of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.ORCID https://orcid.org/0000-0002-6580-809X

Funding

Foundation from the Administration of Traditional Chinese Medicine of Zhejiang Province 2023ZR105National Natural Science Foundation of China 82201510National Natural Science Foundation of China 82471742National Natural Science Foundation of China 82472474Natural Science Foundation of Zhejiang Province LQ22H090016
6 · The paper itself

Abstract

Due to an inhibitory scar microenvironment that prevents neural circuit reconstruction, spinal cord injury (SCI) often leads to persistent neurological dysfunction. Although neonatal murine models demonstrate that microglial inhibition enables scar remodeling to support neuroregeneration and functional recovery, effective pharmacological suppression of microglial activation in adult SCI remain elusive. Here, this work demonstrates that early β2-adrenergic receptor agonist treatment drives microglial transition to a homeostatic phenotype within the post-SCI scar. This intervention reduces inhibitory extracellular matrix deposition and transforms the inhibitory microenvironments into permissive substrates for axonal regrowth. Anatomical analyses reveal regeneration of the reticulospinal tract, which establishes synaptic connectivity with thoracolumbar circuits to mediate motor recovery in a complete SCI. These findings elucidate the therapeutic potential and neural circuit mechanisms underlying pharmacological microglial modulation for SCI repair, establishing a glial-neural circuit reparative paradigm.

Indexed as

CicatrixMicrogliaSpinal Cord InjuriesAnimalsDisease Models, AnimalFemaleMiceMice, Inbred C57BLNerve RegenerationRecovery of FunctionSpinal CordÎ22‐adrenergic receptormicroglial inhibitionmotor function recoveryreticulospinal tractspinal cord injury

Identifiers

PMID41103249
PMCPMC12767085

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.