ReviewFrontiers in pediatrics2025
Combined multichannel intraluminal impedance and pH testing in infants and young children-a narrative review.
Review in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Gastroesophageal Reflux Burden Before and After Exercise Challenge in Children with Poorly Controlled Asthma: A 48-Hour MII-pH Study.Advances in respiratory medicine · 2026Article
- [Research progress and clinical practice considerations on assessment tools for gastroesophageal reflux disease in infants and young children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastroesophageal reflux disease (GERD) is common in infants and young children, and thediagnosis and characterization of the disease continues to evolve in recent times. The typicalsymptoms thought to be related to GERD in young children are often nonspecific andubiquitous, underscoring the need for diagnostic testing in patients who have severe symptomsor complications related to GERD. Combined multichannel intraluminal impedance and pHtesting (MII-pH) is a diagnostic tool that can be used to study the frequency andseverity of gastroesophageal reflux. Compared to other diagnostic devices, MII-pH hasthe advantage of detecting both acidic and alkaline reflux events, as well as allows the study of thetemporal association of symptoms with GER events. Using the diagnostic parameters definedand symptom association data obtained, MII-pH can then be used to classify patients as havingGERD (with either predominantly acid or alkaline reflux), non-erosive reflux disease or NERD (when noevidence of esophagitis is noted on endoscopy), hypersensitive esophagus (positive symptom association only) and functional heartburn (normal study). The application of this disease classification to GERD in young children is relatively new and needs further validation. Even so, classifying GERD into these phenotypes using MII-pH allows for more precise and individualized therapeutic decisions. Emerging research has also suggested MII-pH testing can be used to predict changes in mucosal integrity and study the motility of the esophagus in children. Although the use of MII-pH in children with a large range of disease processes is becoming more widespread, there are important limitations to note in the interpretation of results of MII-pH in young children, due to the relative lack of normative data obtained from truly healthy children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.