ReviewFrontiers in immunology2025
From stress signals to fertility challenges: the role of damage-associated molecular patterns in male reproduction.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Immunological dynamics of the epididymis: from experimental insights to clinical translation.Reproduction & fertility · 2026Review
- Interaction Between Telocytes and Mast Cells in Genetically Determined Non-Obstructive Azoospermia with AZFc Deletion: An Ultrastructural Study.International journal of molecular sciences · 2026Article
- Prostatitis-Related Male Infertility: From Inflammation and Dysbiosis to Sperm DNA Damage.Diagnostics (Basel, Switzerland) · 2026Review
- The seminal plasma sTLR4/IL-1β ratio as an independent factor associated with sperm chromatin condensation defects.Frontiers in physiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Male infertility is influenced by genetic abnormalities, hormonal imbalances, lifestyle factors, and environmental exposures. Recently, Damage-Associated Molecular Patterns (DAMPs) have emerged as key players in male reproductive health, particularly in regulating inflammatory responses and tissue damage. This review highlights the role of critical DAMPs, such as HMGB1, HSPs, ATP, eCIRP, histones, and cfDNA, in processes like spermatogenesis, sperm maturation, and fertilization. Released through mechanisms like necrosis, apoptosis, pyroptosis, and exosomes, DAMPs significantly influence immune regulation, thereby affecting male fertility. Understanding these roles offers new therapeutic avenues targeting DAMPs to improve male reproductive health and treat infertility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.