ArticleFrontiers in endocrinology2025
Per- and polyfluoroalkyl substances in dog blood serum levels and semen quality.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Exploring dog saliva as a non-invasive alternative to blood sampling for chemical exposome studies: analysis of synthetic phenolic antioxidants and PFAS.Frontiers in veterinary science · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Growing evidence links chemical exposure to declining reproductive function in both humans and dogs. Our aim was to investigate the exposure of a wide range of per- and polyfluoroalkyl substances (PFAS) in dog serum and to investigate the association between PFAS exposure and endocrine parameters as well as semen quality. Method: Semen samples (n=65) were collected from Bernese mountain dogs during 2020. Sperm motility was evaluated under a phase-contrast microscope (100×, 200×). Total sperm count was calculated using a Bürker chamber. Sperm morphology was evaluated using standard protocols in wet preparations of semen fixed in buffered formalin and stained with carbolfuchsin-eosin. Serum was analyzed using a combined targeted and suspect screening approach for quantitative analysis of 50 PFAS. Following extraction, instrumental analysis was performed using an ultra-high-performance liquid chromatograph coupled to a Q ExactiveOrbitrap mass spectrometer. PFAS concentrations were associated with semen quality and endocrine biomarkers using Least Absolute Shrinkage and Selection Operator (LASSO) regression. Results: In all samples, PFOA, PFNA, PDFA, PFPeS, PFHxS and PFOS could be detected, although PFPeS levels were not above the quantification limit. The levels of the dominant congeners were on average (5 Conclusion: For the first time, levels of a wide range of target and suspect PFAS are described in dog serum. PFAS levels in dog serum were similar to those in cats and humans, confirming that humans and pets, to a considerable extent, may share exposure to PFAS through the home environment. The study contributes to bridging the existing knowledge gap of exposure to endocrine disruptors and health effects in dogs, and thus to the research infrastructure bridging between species with the benefit of both humans and pets in a true One Health approach.
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Registered trials
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