ArticleFrontiers in medicine2025
"Spider Web"-like zonular deposits in pseudoexfoliation syndrome: endoscopic insights-a case report.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pseudoexfoliation syndrome (PEX) is a systemic fibroproteinopathy with limited global epidemiological data and unclear pathogenesis. This case report describes a 70-year-old Asian woman presenting with left eye soreness and blurred vision. She was diagnosed with PEX based on typical ocular characteristics, including grayish-white debris on the pupillary margin, pigment residues in the anterior chamber angle, and annular opacity around the anterior lens capsule after pupil dilation. During surgery, endoscopic observation revealed extensive grayish-white flocculent deposits covering the entire circumference of the zonules, resembling a spider web-findings consistent with the "fibrin-like deposits" described in autopsy studies. Such exfoliated material may damage the intraocular environment through mechanical damage and chronic inflammatory responses. This is supported by intraoperative anterior chamber depth instability and a markedly elevated interleukin-8 (IL-8) concentration (557.3 pg/mL) in the anterior chamber fluid. This case provides
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