Evidence map›Paper›PMID 41103709›Full record

ArticleFrontiers in medicine2025

A prospective analysis of lymph node retrieval in colorectal cancer: discrepancies, neoadjuvant impact, and practical implications.

Saumik Biswas, Jesse R Walsh, Sami Ul Haq, Ann M Marilley, Elizabeth P Pasman, Monica Kendall, Matthew Cecchini, Grace Lebbin, Darren Wilson

Abstract read
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In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Saumik BiswasDepartment of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Jesse R WalshAdvanced Diagnostics Laboratory, Mayo Clinic, Rochester, MN, United States.
Sami Ul HaqDepartment of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Ann M MarilleyDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States.
Elizabeth P PasmanDepartment of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Monica KendallDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States.
Matthew CecchiniDepartment of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Grace LebbinAdvanced Diagnostics Laboratory, Mayo Clinic, Rochester, MN, United States.
Darren WilsonAdvanced Diagnostics Laboratory, Mayo Clinic, Rochester, MN, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Accurate lymph node (LN) retrieval is vital for colorectal cancer (CRC) staging and determining adjuvant therapy. Methods: In this prospective study of 122 CRC specimens, we evaluated LN retrieval times, discrepancies between gross and microscopic LN counts, and the impact of neoadjuvant therapy. Results: On average, dissecting each specimen took 50 min (range 15-295 min), with rectal and descending/sigmoid colon specimens often requiring multiple passes. Macroscopic dissection yielded an average of 45.1 LNs per specimen, whereas microscopic examination confirmed only 35.7 LNs on average. Neoadjuvant therapy did not alter macroscopic yields ( Discussion: Taken together, these findings emphasize the multifactorial nature of LN retrieval challenges, particularly in neoadjuvant-treated and anatomically complex cases. Refining dissection protocols, leveraging new technologies, and allocating adequate resources may help reduce retrieval errors, potentially improving staging accuracy and clinical decision-making.

Indexed as

colorectal cancereconomicsgrossinglymph nodesmanual dissectionpathologists’ assistant

Identifiers

PMID41103709
PMCPMC12521114

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.