ArticleCureus2025
A Comparative Study of Clinical, Hematological, and Biochemical Profiles in Eosinophilic and Non-eosinophilic Phenotypes of Chronic Obstructive Pulmonary Disease (COPD) During Acute Exacerbations.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
Chronic obstructive pulmonary disease (COPD) continues to be a major global health concern, with emerging evidence suggesting that blood eosinophils may help distinguish between inflammatory subtypes during acute exacerbations. This observational cross-sectional study conducted at Baba Raghav Das (BRD) Medical College, Gorakhpur examined 60 patients with acute COPD exacerbations, categorized into eosinophilic (>300 cells/μL, n=20, 33.1%) and non-eosinophilic (≤300 cells/μL, n=40, 66.9%) phenotypes based on peripheral blood eosinophil counts. Non-eosinophilic patients demonstrated significantly higher systemic inflammation markers, including C-reactive protein levels (17.35 ± 3.8 vs 8.2 ± 5.3 mg/L, p<0.001), neutrophil percentages (79.5 ± 3.5% vs 66.2 ± 4.7%, p<0.001), and hepatic enzymes, along with longer hospital stays (6 vs 4 days, p=0.002). Eosinophilic patients were more likely to receive inhaled corticosteroids (66.0% vs 44.4%), while those with very low eosinophil counts (<150 cells/μL) more frequently received systemic corticosteroids (46.7% vs 19.1%, p=0.023). These findings suggest distinct inflammatory profiles between COPD phenotypes during acute exacerbations and support the potential utility of eosinophil-guided therapeutic approaches, though prospective studies are needed to confirm these associations and their clinical implications.
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