Evidence map›Paper›PMID 41104530›Full record

ArticleCNS neuroscience & therapeutics2025

Elevated Release of Presynaptic Glutamate: The Potential Pathogenesis of Anti-NMDAR Encephalitis-Associated Seizures.

Hongmi Huang, Yifei Huang, Sijun Li, Ying Wu, Shengyu Yang, Yuan Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hongmi HuangDepartment of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
Yifei HuangDepartment of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
Sijun LiDepartment of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.ORCID 0000-0002-6199-4307
Ying WuDepartment of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
Shengyu YangDepartment of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
Yuan WuDepartment of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.

Funding

National Natural Science Foundation of China 82360267
6 · The paper itself

Abstract

backgroundThe pathogenesis of anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDAR encephalitis)-associated seizures remains elusive.

methodsMice were injected with GluN1

resultsFollowing the administration of immunogenic peptide GluN1

conclusionTo the best of our knowledge, this is the first study to demonstrate that increased glutamate release may increase seizure susceptibility in patients with anti-NMDAR encephalitis.

Indexed as

Anti-N-Methyl-D-Aspartate Receptor EncephalitisGlutamic AcidPresynaptic TerminalsSeizuresAction PotentialsAnimalsDisease Models, AnimalElectroencephalographyExcitatory Postsynaptic PotentialsFemaleMaleMiceMice, Inbred C57BLNeuronsPentylenetetrazoleReceptors, N-Methyl-D-AspartateGlutamic AcidPentylenetetrazoleReceptors, N-Methyl-D-Aspartateaction potentialsanti‐NMDAR encephalitisglutamateimmunogenic peptideminiature excitatory postsynaptic currentneuronseizures

Identifiers

PMID41104530
PMCPMC12531711

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.