ReviewCurrent diabetes reports2025
Exosomes and microRNAs: Molecular Mediators Linking Obesity, Exercise, and Metabolic Regulation.
Review in Current diabetes reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Exercise-derived exosomal miR-151-3p: An innovative anti-inflammatory and antioxidant therapeutic for spinal cord injury.Bioactive materials · 2026Article
- Effects of exercise‑derived extracellular vesicles: Epigenetic regulatory mechanisms and protective roles (Review).International journal of molecular medicine · 2026Review
- Exercise-associated microRNA programs as candidate modulators and biomarkers in glioblastoma: a narrative review.Discover oncology · 2026Review
- Editorial: Focus on Exercise Physiology and Sports Performance: 2nd Edition.Life (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purpose of reviewObesity is a global health crisis characterized by chronic inflammation and metabolic dysfunction, partly driven by altered intercellular communication within the adipose tissue. Exosomes, small extracellular vesicles, and their microRNA (miRNA) cargo have emerged as key mediators in this process, facilitating crosstalk between adipose tissue and other organs and influencing insulin sensitivity, inflammation, and energy homeostasis. Physical exercise modulates the expression and secretion of exosomal miRNAs, contributing to systemic metabolic improvements and counteracting obesity-related diseases. This study reviews recent research on the causal role of exosomes in obesity-related metabolic dysfunction. RECENT
findingsExosome-derived miRNAs are often deregulated in obese individuals, promoting adipose tissue hypertrophy, systemic insulin resistance, and chronic inflammation. Specific miRNAs (e.g., miR-34a, miR-29a, miR-222, miR-155, and miR-27a) have been implicated in impairing insulin signaling and promoting pro-inflammatory states. Exercise-induced exomiRs (e.g., miR-1, miR-133b, and miR-22) mediate beneficial effects, such as enhanced lipolysis, improved insulin sensitivity, and reduced inflammation. Experimental models have shown that exosomes from trained animals can transfer these benefits to their sedentary or obese counterparts. Exosomes and their miRNA cargoes are crucial mediators of crosstalk between adipose tissue and other organs, significantly influencing metabolic regulation in obesity. Physical exercise is a potent modulator of exosome-mediated signaling, offering systemic metabolic benefits and potential non-pharmacological interventions.
Indexed as
Identifiers
41105175What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.