Evidence mapPaperPMID 41105455Full record

ArticleJournal of natural products2025

Biosynthesis, Chemical Synthesis, and Pharmacological Evaluation of Lyngbyapeptin A as a GPCR Antagonist of Motilin, Cannabinoid, and Amylin Receptors.

Tam H D Pham, Manyun Chen, Jie Liu, Qi-Yin Chen, Gustavo Seabra, Valerie J Paul, Mohamed S Donia, Steven D Bruner, Yousong Ding, Hendrik Luesch

Abstract read
In one paragraph

Article in Journal of natural products, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tam H D PhamDepartment of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, United States.
Manyun ChenDepartment of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0001-6803-044X
Jie LiuDepartment of Molecular Biology, Princeton University, Princeton, New Jersey 08544, United States.
Qi-Yin ChenDepartment of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, United States.
Gustavo SeabraDepartment of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0002-1303-4483
Valerie J PaulSmithsonian Marine Station, Fort Pierce, Florida 34949, United States.ORCID 0000-0002-4691-1569
Mohamed S DoniaDepartment of Molecular Biology, Princeton University, Princeton, New Jersey 08544, United States.
Steven D BrunerCenter for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0002-0522-480X
Yousong DingDepartment of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0001-8610-0659
Hendrik LueschDepartment of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0002-4091-7492

Funding

Integrative Multidisciplinary Discovery Platform to Unlock Marine Natural Products Therapeutic OpportunitiesRM1GM145426 · UNIVERSITY OF FLORIDA · 2025 to 2025
$1.8M
Accessing and expanding microbial bioactive chemical diversity by synthetic biology and new enzymologyR35GM128742 · UNIVERSITY OF FLORIDA · 2025 to 2025
$364k
NIGMS NIH HHS R35 GM128742NIGMS NIH HHS RM1 GM145426NIH HHS S10 OD028753
6 · The paper itself

Abstract

Lyngbyapeptin A (

Indexed as

Lyngbya ToxinsOligopeptidesReceptors, Gastrointestinal HormoneReceptors, G-Protein-CoupledCyanobacteriaHumansMolecular StructureMultigene FamilyPapua New GuineaReceptors, CannabinoidLyngbya ToxinsOligopeptidesReceptors, CannabinoidReceptors, Gastrointestinal HormoneReceptors, G-Protein-Coupled

Identifiers

PMID41105455
PMCPMC12772116

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.