ArticleTranslational psychiatry2025
Dysfunction of the rostral lateral septum GABAergic neurons induces mania-like behavior in male mice.
Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Manic episodes in bipolar disorder are characterized by hyperactivity, elevated mood, and sleep disturbances. The precise brain regions and neuronal populations underlying these behaviors remain elusive. We demonstrated that chemogenetic inhibition or ablation of rostral lateral septum (LS) GABAergic neurons induced mania-like behaviors in mice, encompassing hyperactivity, reduced anxiety, anti-depressive-like behaviors, and shortened sleep duration. Chronic administration of lithium and valproic acid effectively attenuated hypermobility and normalized elevated mood in these mice. Regarding neural circuit mechanisms, we identified that mania-like behaviors induced by LS GABAergic neuronal dysfunction primarily involve the lateral hypothalamic circuit and, to a lesser extent, the diagonal band of Broca. These findings elucidate the neurobiological mechanisms of manic episodes and identify the LS GABAergic-lateral hypothalamic pathway as a potential therapeutic target for bipolar disorder.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.