ArticleTranslational psychiatry2025
Regularized CCA identifies sex-specific brain-behavior associations in adolescent psychopathology.
Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Distinct associations between multimodal brain measures and psychopathology domains predict adolescent functioning.bioRxiv : the preprint server for biology · 2026Article
- Convergent and divergent brain-cognition development in early adolescence.Nature communications · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
Adolescence is a critical period of neural development and a sensitive window for the emergence of psychiatric symptoms. Resting-state functional MRI (rs-fMRI) provides a unique opportunity to investigate brain-behavior associations. However, the role of sex-specific differences in these associations remains underexplored, despite their potential to reveal heterogeneous neurobiological mechanisms and guide personalized interventions. In this study, we analyzed data from the Adolescent Brain Cognitive Development (ABCD) Study, comprising 7,892 adolescents (9-10 years old, 3,896 females). Using Canonical Correlation Analysis (CCA) and a rigorous cross-validation framework, we identified associations between cortical-to-cortical (Cor-Cor) and cortical-to-subcortical (Cor-Sub) functional connectivity and eight symptom domains from the Child Behavior Checklist (CBCL). Unlike previous approaches, we directly examined sex differences within the brain-behavior mappings by applying separate CCA models in boys and girls to uncover differential connectivity-behavior relationships. Our analysis uncovered two reproducible components for both Cor-Cor and Cor-Sub mappings on the whole cohort (r
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Registered trials
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