ArticleTranslational psychiatry2025
Modulation of brain oscillations by continuous theta burst stimulation in patients with insomnia.
Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Repeated Continuous Theta-Burst Stimulation Modulates Resting-State EEG Microstate Dynamics in Athletes with Chronic Insomnia.Brain sciences · 2026Article
- Neurovascular Signaling at the Gliovascular Interface: From Flow Regulation to Cognitive Energy Coupling.International journal of molecular sciences · 2025Review
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15 authors.
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Abstract
Continuous theta burst stimulation (cTBS) induces long-lasting depression of cortical excitability in motor cortex. In the present study, we explored the modulation of cTBS on resting state electroencephalogram (rsEEG) during wakefulness and subsequent sleep in patients with insomnia disorder. Forty-one patients with insomnia received three sessions active and sham cTBS in a counterbalanced crossover design. Each session comprised 600 pulses over right dorsolateral prefrontal cortex. Closed-eyes rsEEG were recorded at before and after each session. Effects of cTBS in subsequent sleep were measured by overnight polysomnography screening. Power spectral density (PSD) and phase locking value (PLV) were used to calculate changes in spectral power and phase synchronization after cTBS during wakefulness and subsequent sleep. Compared with sham cTBS intervention, PSD of delta and theta bands were increased across global brain regions with a cumulative effect after three active cTBS sessions. PLV of delta and theta bands were enhanced between stimulated frontal area and occipital areas. Efficiency of information communication within frontal-occipital networks was consistently improved through three active sessions. Increased theta power during wakefulness was positively related with that during the first sleep cycle. Active cTBS significantly enhanced the spectral power of delta and theta bands during wakefulness, with a cumulative effect observed over time. This modulation also extended to influence theta power during subsequent sleep onset period. Collectively, these findings provide a robust theoretical foundation for further investigating the therapeutic potential of long-term cTBS in the treatment of insomnia disorders.
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