Evidence map›Paper›PMID 41107255›Full record

ArticleTranslational psychiatry2025

The impact of musical intervention during fetal and infant stages on social behavior and neurodevelopment in mice.

Rui Qiu, Liguo Li, Ya Su, Qiang Fu, Zhizheng He, Tongtong Yao, Hanyue Chen, Hao Zhang, Yuewen Chen, Wen Qi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rui Qiu *Institute of National Security, Center on Translational Neuroscience, Minzu University of China, Beijing, China.
Liguo Li *Institute of Rehabilitation Medicine, Henan Academy of Innovations in Medical Science, Zhengzhou, China. 1206841199@qq.com.
Ya SuInstitute of Rehabilitation Medicine, Henan Academy of Innovations in Medical Science, Zhengzhou, China.
Qiang FuInstitute of National Security, Center on Translational Neuroscience, Minzu University of China, Beijing, China.
Zhizheng HeInstitute of National Security, Center on Translational Neuroscience, Minzu University of China, Beijing, China.
Tongtong YaoInstitute of National Security, Center on Translational Neuroscience, Minzu University of China, Beijing, China.
Hanyue ChenCollege of Life and Environmental Sciences, Minzu University of China, Beijing, China.
Hao ZhangCollege of Life and Environmental Sciences, Minzu University of China, Beijing, China.
Yuewen ChenChinese Academy of Sciences Key Laboratory of Brain Connectome and Manipulation, Shenzhen Key Laboratory of Translational Research for Brain Diseases, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, Guangdong, China.
Wen QiCollege of Dance, Minzu University of China, Beijing, China. wonderful_qi@126.com.
Yong ChengInstitute of National Security, Center on Translational Neuroscience, Minzu University of China, Beijing, China. yongcheng@muc.edu.cn.ORCID http://orcid.org/0000-0002-7529-4408

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The potential benefits of music in prenatal and early childhood education are widely acknowledged, yet the neurobiological mechanisms underlying its effects on social behavior, particularly during early development, remain underexplored. This study investigated the impact of musical intervention on social behavior and neurodevelopment in mice, focusing on mechanisms at various developmental stages. Pregnant mice were exposed to music starting at embryonic day 13 (E13) and continuing until postnatal weeks 1, 3, or 5. Behavioral tests, including three-chamber social task and social interaction assays, revealed that musical exposure significantly enhanced social interaction in adult mice. mRNA sequencing revealed notable changes in the expression of genes associated with social behavior in both the medial prefrontal cortex (mPFC) and the amygdala. Additionally, Golgi staining demonstrated increased dendritic complexity, spine density, and dendritic length in these regions following music exposure. Elevated MAP2 expression was observed in the mPFC and amygdala, whereas GFAP expression was reduced in the amygdala. These findings provide valuable insights into the neurobiological mechanisms by which music affects early development and underscore its potential as a noninvasive tool to promote social and emotional well-being. This research has implications for therapeutic interventions in individuals with neurodevelopmental disorders, including autism spectrum disorder (ASD).

Indexed as

AmygdalaBehavior, AnimalMusicMusic TherapyPrefrontal CortexSocial BehaviorSocial InteractionAnimalsFemaleMaleMiceMice, Inbred C57BLPregnancy

Identifiers

PMID41107255
PMCPMC12534615

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.