ArticleScientific reports2025
pH-triggered liposomal strategy for cisplatin in lung cancer therapy.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Physicochemical Characterization, Antimicrobial and Antibiofilm Activities ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Liposomal drug delivery for lung cancer therapy: progress, challenges, and future perspectives.Molecular cancer · 2026Review
- Tamoxifen loaded lipid nanoparticles as a novel therapeutic approach enhancing apoptotic cell death in triple negative breast cancer cells.Discover nano · 2026Article
- Parenteral Berberine vs Cisplatin- Loaded Lipid Nanoparticles - Development, Characterisation, Comparative Safety Profiling and Cytotoxicity in Cholangiocarcinoma Cell Models.Nanotechnology, science and applications · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cisplatin (Cis) is the first-line chemotherapy for treating the non-small-cell lung cancer. However, its low solubility, low bioavailability, and potential side effects limit its use. To overcome these drawbacks, novel pH-sensitive liposomal Cis formulations have been developed using a rapid and practical ethanol injection technique. In this study, two different liposome types were prepared, one based on phosphatidylcholine and cholesteryl hemisuccinate (CHEMS), the other containing 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) in combination with CHEMS. Their homogeneity, smaller particle sizes (< 200 nm) and drug integration were confirmed using the DLS method and FT-IR and SEM-EDS, respectively. The loading efficiency was changed from 35 to 50% depending on the composition. In vitro drug release studies showed a minimum release at physiological pH (7.4) and a significantly increased release at acidic pH (5.5), in particularly for DOPE liposomes, indicating the higher pH-sensitivity. Cytotoxicity analyses performed in A549 lung cancer cell line showed that both liposomal formulations exhibited stronger antitumour effects compared to free Cis. This effect was supported by increased apoptotic activity confirmed by Annexin-V/PI staining method. These findings suggest that the pH-sensitive liposomes developed in this study offer a promising and scalable approach to enhance the selective delivery and therapeutic efficacy of Cis.
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