Evidence map›Paper›PMID 41107403›Full record

ArticleActa pharmacologica Sinica2026

Inhibiting mPGES-2 impedes renal cyst growth in mice with polycystic kidney disease.

Dan-Dan Zhong, Cheng Hu, Lan-Lan Zhao, Yan Shen, Ru-Meng Zhang, Ying Liu, Bu-Hui Liu, Wen Su, Bao-Xue Yang, Hui Xiong and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dan-Dan Zhong *Jiangsu Key Laboratory of Geriatric Precision Medicine and Aging Intervention, Xuzhou Medical University, Xuzhou, 221004, China.
Cheng Hu *Jiangsu Key Laboratory of Geriatric Precision Medicine and Aging Intervention, Xuzhou Medical University, Xuzhou, 221004, China.
Lan-Lan Zhao *Jiangsu Key Laboratory of Geriatric Precision Medicine and Aging Intervention, Xuzhou Medical University, Xuzhou, 221004, China.
Yan ShenJiangsu Key Laboratory of Geriatric Precision Medicine and Aging Intervention, Xuzhou Medical University, Xuzhou, 221004, China.
Ru-Meng ZhangDepartment of Pharmacology, Xuzhou Central Hospital, Xuzhou, 221009, China.
Ying LiuDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, 410008, China.
Bu-Hui LiuJiangsu Key Laboratory of Geriatric Precision Medicine and Aging Intervention, Xuzhou Medical University, Xuzhou, 221004, China.
Wen SuDepartment of Pathophysiology, Shenzhen University, Shenzhen, 518060, China.
Bao-Xue YangState Key Laboratory of Vascular Homeostasis and Remodeling, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
Hui XiongDepartment of Urology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Ji-nan, 250021, China.
Dong GuoJiangsu Key Laboratory of Geriatric Precision Medicine and Aging Intervention, Xuzhou Medical University, Xuzhou, 221004, China.
Dong SunClinical Research Center for Kidney Disease, Xuzhou Medical University, Xuzhou, 221004, China. sundongxz@126.com.
Ying-Ying ZouJiangsu Key Laboratory of Geriatric Precision Medicine and Aging Intervention, Xuzhou Medical University, Xuzhou, 221004, China. zouyy2378@xzhmu.edu.cn.
Ying SunJiangsu Key Laboratory of Geriatric Precision Medicine and Aging Intervention, Xuzhou Medical University, Xuzhou, 221004, China. yingsun@xzhmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of multiple fluid-filled cysts in the kidneys, resulting in progressive decline and failure of renal function. Microsomal prostaglandin E synthase-2 (mPGES-2) is a unique bifunctional enzyme that catalyzes the conversion of prostaglandin H

Indexed as

Polycystic Kidney, Autosomal DominantProstaglandin-E SynthasesAnimalsCell ProliferationDinoprostoneDisease Models, AnimalHumansKidneyMaleMiceMice, Inbred C57BLMice, KnockoutDinoprostoneProstaglandin-E SynthasesPtges2 protein, mouseADPKDmPGES-2PGE2proliferationSZ0232β-catenin/STAT3

Identifiers

PMID41107403
PMCPMC12932804

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.