Evidence map›Paper›PMID 41107464›Full record

ArticleCommunications medicine2025

Visceral adipose tissue and hepatic fat as determinants of carotid atherosclerosis.

Russell J de Souza, Marie E Pigeyre, Karleen M Schulze, Amel Lamri, Baraa K Al-Khazraji, Philip Awadalla, Joseph Beyene, Dipika Desai, Jean-Pierre Despres, Trevor J B Dummer and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Russell J de SouzaDepartment of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.ORCID http://orcid.org/0000-0001-8945-513X
Marie E PigeyrePopulation Health Research Institute, Hamilton Health Sciences Corporation, Hamilton, ON, Canada.ORCID http://orcid.org/0000-0003-2984-8366
Karleen M SchulzePopulation Health Research Institute, Hamilton Health Sciences Corporation, Hamilton, ON, Canada.ORCID http://orcid.org/0000-0002-7481-5697
Amel LamriPopulation Health Research Institute, Hamilton Health Sciences Corporation, Hamilton, ON, Canada.
Baraa K Al-KhazrajiDepartment of Kinesiology, Faculty of Science, McMaster University, Hamilton, ON, Canada.
Philip AwadallaOntario Institute for Cancer Research, Toronto, ON, Canada.
Joseph BeyeneDepartment of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Dipika DesaiDepartment of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
Jean-Pierre DespresCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Québec, QC, Canada.
Trevor J B DummerSchool of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
Matthias G FriedrichDivision of Cardiology, McGill University Health Centre, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-1204-5647
Jason HicksAtlantic PATH, Dalhousie University, Halifax, NS, Canada.
Vikki HoUniversité de Montréal Hospital Research Centre (CRCHUM), Montreal, QC, Canada.
Éric LaRoseCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Québec, QC, Canada.
Scott A LearFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
Douglas S LeeInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada.
Jonathon A LeipsicDepartment of Medicine, University of British Columbia, Vancouver, BC, Canada.
Guillaume LettreMontreal Heart Institute, Montréal, QC, Canada.ORCID http://orcid.org/0000-0002-7740-3399
Alan R MoodySunnybrook Health Science Centre, Toronto, ON, Canada.
Michael D NoseworthyImaging Research Centre, St. Joseph's Healthcare, Hamilton, ON, Canada.ORCID http://orcid.org/0000-0003-1464-159X
Guillaume PareDepartment of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.ORCID http://orcid.org/0000-0002-6795-4760
Grace ParragaRobarts Research Institute, The University of Western Ontario, London, ON, Canada.
Paul PoirierCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec-Université Laval, Québec, QC, Canada.
Jean-Claude TardifMontreal Heart Institute, Montréal, QC, Canada.ORCID http://orcid.org/0000-0002-8200-8983
Salim YusufPopulation Health Research Institute, Hamilton Health Sciences Corporation, Hamilton, ON, Canada.
Jennifer VenaAlberta's Tomorrow Project, Alberta Health Services, Calgary, AB, Canada.
Sonia S AnandDepartment of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada. anands@mcmaster.ca.ORCID http://orcid.org/0000-0003-3692-7441

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVisceral adipose tissue (VAT) and hepatic fat (HF) contribute to multiple health risks, including diabetes, hypertension, cardiovascular disease, cognitive decline, and cancer. The objective of this study is to determine whether VAT and HF are associated with carotid atherosclerosis beyond traditional cardiovascular risk factors.

methodsParticipants in the Canadian Alliance of Healthy Hearts and Minds (CAHHM) cohort study (n = 6760; average age= 57.1; 54.9% female) underwent MRI for VAT volume, hepatic fat fraction (HFF), and carotid atherosclerosis assessed by carotid wall volume (CWV). Regression models were used to assess the associations of VAT and HF with carotid atherosclerosis, separately in males and females, controlling for other cardiovascular risk factors. Associations of VAT and proton-density hepatic fat fraction (PDFF) with ultrasound-measured carotid-intima media thickness (CIMT) were also assessed in the UK Biobank (UKB; n = 26,547; average age = 54.7; 51.9% female).

resultsIn CAHHM, we show that a 1-SD higher VAT volume is associated with a 6.16 mm³ higher CWV (95% CI: 1.68 to 10.63), but there is no association between HFF and CWV. In the UK Biobank cohort, a 1-SD higher VAT volume is associated with a 0.016 ± 0.009 mm higher CIMT, and a 1-SD higher PDFF is associated with a 0.012 ± 0.010 mm higher CIMT. After adjustment for CV risk factors, these associations are attenuated. A pooled analyses of CAHHM and UKB support a direct, positive association of VAT and HFF with subclinical atherosclerosis in both sexes, albeit slightly weaker for hepatic fat.

conclusionVisceral fat, and to a lesser extent, hepatic fat, are associated with increased carotid atherosclerosis.

Identifiers

PMID41107464
PMCPMC12534607

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.