Evidence map›Paper›PMID 41107529›Full record

ArticleScientific reports2025

Targeted proteomics analysis in type 1 diabetes identifies lower agouti-related protein levels in individuals with impaired hypoglycaemia awareness.

Rita D M Varkevisser, Agnese Petrera, Stefanie M Hauck, Dick Mul, Henk-Jan Aanstoot, Andrew Paterson, Bruce H R Wolffenbuttel, Melanie M van der Klauw, Dutch Type 1 Diabetes Biomarker Group

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rita D M VarkevisserDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. r.d.m.varkevisser@umcg.nl.ORCID https://orcid.org/0000-0002-5656-6244
Agnese PetreraMetabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.ORCID https://orcid.org/0000-0002-0583-6195
Stefanie M HauckMetabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.ORCID https://orcid.org/0000-0002-1630-6827
Dick MulDiabeter Netherlands, Center for Type 1 Diabetes Care and Research, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-8095-9155
Henk-Jan AanstootDiabeter Netherlands, Center for Type 1 Diabetes Care and Research, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-5534-1633
Andrew PatersonGenetics and Genome Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-9169-118X
Bruce H R WolffenbuttelDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0001-9262-6921
Melanie M van der KlauwDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID https://orcid.org/0000-0001-7178-009X
Dutch Type 1 Diabetes Biomarker Group

Funding

Diabetes Fonds 2015.16.1856Juvenile Diabetes Research Foundation Netherlands 3-SRA-2014-291-M-R
6 · The paper itself

Abstract

Impaired awareness of hypoglycaemia (IAH) is a complication of diabetes treatment, whereby individuals are no longer able to feel an oncoming hypoglycaemic event. IAH may be a result of central nervous system adaptation to low recurrent hypoglycaemias, however the precise pathways involved remain unknown. This study employed proteomics analysis to explore potential pathophysiological pathways in IAH, using a nested case-control design within the Dutch Type 1 Diabetes Biomarker study. The Olink

Indexed as

Agouti-Related ProteinDiabetes Mellitus, Type 1HypoglycemiaProteomicsAdultAwarenessBiomarkersCase-Control StudiesFemaleHumansMaleMiddle AgedAgouti-Related ProteinAGRP protein, humanBiomarkersHypoglycaemiaImpaired awareness of hypoglycaemiaType 1 diabetes

Identifiers

PMID41107529
PMCPMC12534408

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.