ArticleBMC medical imaging2025
Ensemble deep learning model for accurate assessment of renal fibrosis in chronic kidney disease using two-dimensional shear wave elastography images.
Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Kidney Elastography in Adult Nephrology: A Narrative Review.Diagnostics (Basel, Switzerland) · 2026Review
- Quantitative MRI of pediatric chronic kidney disease and renal fibrosis: potential non-invasive clinical biomarkers.Pediatric radiology · 2026Review
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Authors and funding
9 authors.
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Abstract
backgroundThe accuracy of shear wave elastography for non-invasive assessment of renal fibrosis (RF) in chronic kidney disease (CKD) needs further improvement. We developed a tool using an ensemble deep learning model (EDLM) that can accurately assess RF in CKD patients based solely on two-dimensional shear wave elastography (2D-SWE) images.
methodsRetrospective data were collected from CKD patients between April 2019 and October 2024, along with renal 2D-SWE images obtained before biopsy. Pathological evaluation was the reference standard of RF. All patients were randomly divided into training, validation, and test sets in a 7:1:2 ratio. An EDLM integrating three convolutional neural networks (ResNet18, DenseNet121, and EfficientNet-b7) through a voting strategy at the output level was developed and validated using 2D-SWE images. The diagnostic performance of the EDLM was compared with that of radiologists.
resultsA total of 286 CKD patients (mean age ± standard deviation: 41.86 ± 14.94, males: 162) and 858 2D-SWE images (mild RF: 405, moderate-severe RF: 453) were included. In the test set, EDLM achieved an accuracy of 93.0% (95% CI: 88.1, 95.9), negative predictive value of 89.6% (95% CI: 81.5, 94.5), positive predictive value of 96.4% (95% CI: 90.0, 98.8), specificity of 96.3% (95% CI: 89.7, 98.7), and sensitivity of 90.0% (95% CI: 82.1, 94.7). The area under the receiver operating characteristic curves of the EDLM was 0.989, surpassing experienced radiologist by 0.186 (P < 0.001) and less experienced radiologist by 0.279 (P < 0.001).
conclusionEDLM based on 2D-SWE images significantly improved the diagnostic performance of RF in CKD. The EDLM was expected to be a potential tool for accurately non-invasive assessment of RF in CKD.
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