Evidence map›Paper›PMID 41108065›Full record

ReviewAngiology2026

Autologous Cell Therapy for Chronic Limb Threatening Ischemia: Towards Personalized Medicine.

Eugenio Caradonna, Francesco Setacci, Jessica Lanza, Fulvio Ferrara, Carlo Setacci, Massimo Danese, Gaetano Lanza

Abstract readReview
In one paragraph

Review in Angiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eugenio CaradonnaDepartment of Pathology and Laboratory Medicine, Centro Diagnostico Italiano, Milan, Italy.
Francesco SetacciKore University of Enna, Italy.
Jessica LanzaDepartment of Surgical and Integrated Diagnostic Sciences, University of Genoa, Italy.
Fulvio FerraraDepartment of Pathology and Laboratory Medicine, Centro Diagnostico Italiano, Milan, Italy.
Carlo SetacciVascular and Endovascular Surgery Department and Residency Program in Vascular Surgery, University of Siena, Italy.
Massimo DaneseUOSD of Regenerative Medicine, Ospedale San Giovanni Addolorata, Rome, Italy.
Gaetano LanzaDepartment of Vascular Surgery, IRCCS Policlinico Multimedica, Sesto San Giovanni, Milan, Italy.ORCID 0000-0003-4018-9971

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral Artery Disease (PAD) with Chronic Limb Threatening Ischemia (CLTI) is a severe condition at risk of amputation, and often conventional surgical and endovascular procedures and/or medical therapy are insufficient. The present review considers current knowledge regarding autologous cell therapy and regenerative medicine for PAD with CLTI. We evaluated cell-based therapies in the recent literature, that are pivotal in treating vascular disorders by promoting angiogenesis, vascular restoration, and tissue regeneration; furthermore, we provided an overview of the relevant main clinical studies. Clinical conditions and risk factors of patients correlate with the performance of autologous cell-based therapies and the probability of success. Nevertheless, the current evidence indicates that these therapies are promising, necessitating further research. Autologous cell therapy and regenerative medicine can offer additional support for treating PAD with CLTI. These advanced techniques are becoming more tailored and substantial for their application in clinical practice. Personalized Medicine represents a contemporary paradigm that calls for consideration of individual patient's clinical conditions, risk factors, and biomarkers.

Indexed as

Chronic Limb-Threatening IschemiaIschemiaPeripheral Arterial DiseasePrecision MedicineStem Cell TransplantationAnimalsChronic DiseaseHumansNeovascularization, PhysiologicRisk FactorsTransplantation, AutologousTreatment Outcomeautologous cell therapychronic limb threatening ischemiapersonalized medicine

Identifiers

PMID41108065
PMCPMC13379602

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.