Evidence map›Paper›PMID 41108452›Full record

ArticleInternational ophthalmology2025

Patient-reported visual difficulties associated with geographic atrophy from age-related macular degeneration.

Liangbo Linus Shen, Carol A Applegate, Gary S Rubin, Janet S Sunness

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Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Liangbo Linus ShenDepartment of Ophthalmology, Duke University, Durham, NC, USA.
Carol A ApplegateRichard E. Hoover Low Vision Rehabilitation Services and Department of Ophthalmology, Greater Baltimore Medical Center, Baltimore, MD, USA.
Gary S RubinNIHR Biomedical Research Centre for Ophthalmology at Moorfields Eye Hospital, London, UK.
Janet S SunnessRichard E. Hoover Low Vision Rehabilitation Services and Department of Ophthalmology, Greater Baltimore Medical Center, Baltimore, MD, USA. JSunness@gbmc.org.

Funding

NIH HHS R01EY08552
6 · The paper itself

Abstract

purposeTo characterize visual difficulties associated with geographic atrophy (GA).

methodsA prospective study included 91 participants with bilateral GA. A visual activities questionnaire was administered at baseline and annually for 2 years along with best-corrected visual acuity (BCVA) and GA size. Baseline questionnaire responses were compared using logistic regressions, and longitudinal changes were analyzed with generalized linear mixed-effect models. A small group of 12 participants with drusen without GA served as a comparison to participants with GA and good VA.

resultsCompared to drusen participants, bilateral GA participants with BCVA of 20/50 or better reported significantly more difficulties in 8 vision-specific tasks. The frequencies of difficulty in reading small print, trouble with face recognition, and stopping driving were positively associated with GA severity cross-sectionally, measured by either BCVA or GA size, and increased over 2 years (P < 0.05 for each). Additional significant longitudinal changes included difficulty seeing in dim light (P = 0.005) and locating a sign (P = 0.008).

conclusionReading, vision in dim illumination, face recognition, locating signs, and driving worsen over 2 years in patients with GA, and may be the appropriate self-reported items to monitor in a clinical trial. These findings highlight the need for therapies addressing both GA enlargement and visual function decline.

Indexed as

Geographic AtrophyMacular DegenerationVision DisordersVisual AcuityAgedAged, 80 and overCross-Sectional StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesSurveys and QuestionnairesTomography, Optical CoherenceAge-related macular degenerationBest-corrected visual acuityGeographic atrophyQuality of lifeVisual activities questionnaireVisual function

Identifiers

PMID41108452

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.