Evidence map›Paper›PMID 41109432›Full record

SynthesisAdvances in nutrition (Bethesda, Md.)2025

Plant-Based Diets and Cognitive Outcomes: A Systematic Review and Meta-analysis.

Catherine Bigras, Riccardo Mazzoli, Danielle Laurin, Marcella Malavolti, Giulia Barbolini, Marco Vinceti, Jean-Philippe Drouin-Chartier, Tommaso Filippini

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Advances in nutrition (Bethesda, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Catherine BigrasFaculté de pharmacie, Université Laval, Québec, Canada; Centre Nutrition, santé et société (NUTRISS), Université Laval, Québec, Canada; Institut sur la nutrition et les aliments fonctionnels, Université Laval, Québec, Canada; Centre de recherche du CHU de Québec- Université Laval, Axe Santé des populations et pratiques optimales en santé, Centre d'excellence sur le vieillissement de Québec, Québec, Canada.
Riccardo MazzoliCREAGEN - Environmental, Genetic and Nutritional Epidemiology Research Center, Section of Public Health, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Danielle LaurinFaculté de pharmacie, Université Laval, Québec, Canada; Institut sur la nutrition et les aliments fonctionnels, Université Laval, Québec, Canada; Centre de recherche du CHU de Québec- Université Laval, Axe Santé des populations et pratiques optimales en santé, Centre d'excellence sur le vieillissement de Québec, Québec, Canada.
Marcella MalavoltiCREAGEN - Environmental, Genetic and Nutritional Epidemiology Research Center, Section of Public Health, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Giulia BarboliniDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, United States.
Marco VincetiCREAGEN - Environmental, Genetic and Nutritional Epidemiology Research Center, Section of Public Health, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; Department of Epidemiology, Boston University School of Public Health, Boston, MA, United States.
Jean-Philippe Drouin-ChartierFaculté de pharmacie, Université Laval, Québec, Canada; Centre Nutrition, santé et société (NUTRISS), Université Laval, Québec, Canada; Institut sur la nutrition et les aliments fonctionnels, Université Laval, Québec, Canada. Electronic address: jean-philippe.drouin-chartier@pha.ulaval.ca.
Tommaso FilippiniCREAGEN - Environmental, Genetic and Nutritional Epidemiology Research Center, Section of Public Health, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; School of Public Health, University of California Berkeley, Berkeley, CA, United States. Electronic address: tommaso.filippini@unimore.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although plant-rich dietary patterns like the Mediterranean and Mediterranean-DASH Intervention for Neurodegenerative Delay diets have been linked to cognitive benefits, the role of predominantly plant-based diets is less understood. This systematic review aimed to evaluate the association between plant-based diets and cognitive outcomes. A literature search was conducted in Medline and Embase using keywords related to plant-based diets (e.g., "vegetarian diet") and cognitive outcomes (e.g., "dementia"). Studies of any design were eligible. Reviewers independently screened studies, extracted data, and assessed quality using the Newcastle-Ottawa Scale. Meta-analyses were conducted on prospective studies that examined the same dietary exposure and cognitive outcome, using fixed-effects regression models. Twenty-two studies were included, with considerable variability in methodologies and outcomes. Plant-based diets were defined either categorically (e.g., vegetarian compared with nonvegetarian), or using indices of adherence, such as the healthful plant-based diet index (hPDI), with higher scores reflecting higher adherence. Two meta-analyses, each based on 2 high-quality prospective cohort studies, examined associations between plant-based diet indices and cognitive outcomes. For cognitive impairment, pooled odds ratios (95% confidence interval) for highest compared with lowest quartiles were 0.61 (0.55, 0.68; I

Indexed as

CognitionCognitive DysfunctionDementiaDiet, VegetarianDiet, Plant-BasedHumanscognitive declinecognitive impairmentdementiaplant-based dietvegetarian diet

Identifiers

PMID41109432
PMCPMC12637054

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.