Evidence map›Paper›PMID 41110464›Full record

ArticleJournal of physical activity & health2026

The Mediating Effect of 24-Hour Movement Behaviors on Mortality Risk in Chronic Kidney Disease: A Compositional Mediation and Life Expectancy Analysis.

Zhehao Wang, Yiting Huang, Jing Xu, Wayne R Lawrence, Jiade Chen, Yutai Cai, Tao Zhang, Qiaoman Mo, Yanhui Gao, Ziqiang Lin

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In one paragraph

Article in Journal of physical activity & health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Zhehao WangDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, GD, China.ORCID 0009-0007-0140-521X
Yiting HuangDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, GD, China.
Jing XuDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, GD, China.
Wayne R LawrenceDepartment of Epidemiology and Biostatistics, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA.
Jiade ChenDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, GD, China.
Yutai CaiDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, GD, China.
Tao ZhangDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, GD, China.
Qiaoman MoDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, GD, China.
Yanhui GaoDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, GD, China.
Ziqiang LinDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, GD, China.ORCID 0000-0003-1990-6788

Funding

The Endowment for Community-based Health Disparities Research and TrainingS21MD010692 · NIMHD · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI RODRIGUEZ, HAVIDAN, SCHELL, LAWRENCE M · 2016 to 2020
$10.0M
NIMHD NIH HHS S21 MD010692
6 · The paper itself

Abstract

backgroundTo investigate the mediating effect of 24-hour movement behaviors on the relationship between chronic kidney disease (CKD) and mortality risk; additionally, to assess the health benefits of reallocating sedentary behavior (SB) with physical activity.

methodsThis prospective cohort study included 88,795 participants (aged 43-78) from the UK Biobank with valid accelerometer data. A compositional mediation model assessed whether 24-hour movement behaviors mediate the CKD-mortality association. A flexible parametric hazards model was used to estimate life expectancy under various reallocation scenarios of 24-hour movement behaviors.

resultsDuring a median follow-up of 8.10 years, 3673 participants met CKD criteria, and 3117 died. CKD increased all-cause mortality risk through greater SB and reduced light-intensity physical activity and moderate to vigorous physical activity (MVPA; hazard ratios = 1.040; 95% confidence interval, 1.030-1.050). Reallocating 20 minutes per day of SB to MVPA increased life expectancy by 1.70 years at age 45 (95% confidence interval, 0.51-4.34).

conclusionsTwenty four-hour movement behaviors partially mediate mortality risk in CKD, with MVPA showing the strongest protective effect. Interventions that reduce SB and increase MVPA can improve survival in CKD populations.

Indexed as

ExerciseLife ExpectancyRenal Insufficiency, ChronicSedentary BehaviorAccelerometryAdultAgedFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsUnited Kingdomcompositional mediation modelisotemporal substitutionphysical activity

Identifiers

PMID41110464
PMCPMC12914270

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.