ArticleBMC pediatrics2025
The rising threat of antibiotic and multidrug resistance in neonatal urinary tract infections.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Biofilm-Mediated Antimicrobial Resistance in PediatricAntibiotics (Basel, Switzerland) · 2026Review
- Safeguarding future generations: a One Health perspective on children, climate change, and infectious threats.Frontiers in public health · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTıVE: Urinary tract infections (UTIs) are one of the significant causes of sepsis in neonates. Currently, antimicrobial resistance (AMR) and multidrug-resistant (MDR) microorganisms have become an increasingly prevalent issue in newborns. This study aimed to evaluate the clinical and laboratory findings, causative organisms, associated urinary tract anomalies, AMR patterns, and factors influencing the development of MDR in neonatal UTIs.
methodsMicroorganisms in urine cultures obtained through bladder catheterization from neonates were identified, and AMR profiles as well as MDR organisms were determined. Antibiotic susceptibility tests were performed using Kirby-Bauer disk diffusion method and VITEK 2 Compact system. The cultures were categorized into two groups: MDR and non-MDR. A retrospective evaluation was conducted to assess the impact of clinical, laboratory, and imaging data on the development of MDR.
resultsData from 51 neonatal UTIs between 2018 and 2024 were evaluated. The most common microorganisms were Esherichia coli (E. Coli) and Klebsiella pneumoniae (K. Pneumoniae). A total of 75% of the E. coli strains demonstrated resistance to ampicillin. Resistance rates of E. coli, K. pneumoniae, and Enterobacter spp. to gentamicin was 25%, 30.7%, and 80%, respectively. Among the microorganisms 55% of E. coli, 100% of Enterobacter spp., 38.5% of K. pneumoniae, and 20% of Enterococcus spp. were MDR. However, no significant correlation was found between MDR and clinical, laboratory, and imaging data. Blood cultures were obtained from all patients prior to the initiation of antibiotic therapy; however, no pathogenic microorganisms were isolated.
conclusionsAMR and MDR in neonatal UTIs appear to be a serious problem. Treatment options in MDR UTIs remain limited, and it is particularly important to research on the pharmacokinetics and safety profiles of antimicrobials in children is essential to expand treatment options for pediatric populations worldwide.
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