Evidence map›Paper›PMID 41111319›Full record

ArticleEuropean psychiatry : the journal of the Association of European Psychiatrists2025

The moderating effect of lifetime physical activity on brain alterations related to adverse childhood experiences.

Lemye Zehirlioglu, Traute Demirakca, Richard Nkrumah, Lennart Ettingshausen, Yasmin Grauduszus, Claudius von Schröder, Melissa Feichtmair, Nikolaus Kleindienst, Gabriele Ende, Christian Schmahl

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Article in European psychiatry : the journal of the Association of European Psychiatrists, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lemye ZehirliogluDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID https://orcid.org/0000-0003-4154-0348
Traute DemirakcaGerman Center for Mental Health (DZPG), Partner Site Mannheim - Heidelberg, Ulm, Germany.
Richard NkrumahGerman Center for Mental Health (DZPG), Partner Site Mannheim - Heidelberg, Ulm, Germany.ORCID https://orcid.org/0000-0002-3559-9338
Lennart EttingshausenDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Yasmin GrauduszusDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID https://orcid.org/0009-0006-2474-5295
Claudius von SchröderDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID https://orcid.org/0009-0002-5188-3053
Melissa FeichtmairGerman Center for Mental Health (DZPG), Partner Site Mannheim - Heidelberg, Ulm, Germany.ORCID https://orcid.org/0009-0002-8606-3792
Nikolaus KleindienstDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID https://orcid.org/0000-0002-1696-2488
Gabriele EndeGerman Center for Mental Health (DZPG), Partner Site Mannheim - Heidelberg, Ulm, Germany.ORCID https://orcid.org/0000-0002-8778-771X
Christian SchmahlDepartment of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Funding

Deutsche Forschungsgemeinschaft GRK2350/2
6 · The paper itself

Abstract

backgroundAdverse childhood experiences (ACEs) can cause morphological brain alterations across the lifespan, contributing to increased vulnerability to mental and physical disorders. Despite extensive research on ACEs-related brain alterations, the protective or augmenting role of modifiable lifestyle factors such as physical activity has been largely underexplored, representing a key gap in our understanding of trauma-related neuroplasticity. To close this gap, we aimed to investigate how lifetime physical activity (LPA) influences the relationship between ACEs and morphological brain alterations.

methodsModeration analyses using Hayes' PROCESS macro examined the interaction between ACEs and LPA on the volume of limbic system-related regions - hippocampus, amygdala, anterior cingulate cortex (

resultsWhile LPA showed no moderating effect on hippocampal or anterior cingulate volume, the model concerning the volume of the amygdala was significant. This model explained 8.1% of the variance in amygdala volume (

conclusionsOur findings underscore the behavioral dependency of the structural adaptations of the amygdala following childhood adversities. These results emphasize the therapeutic potential of incorporating physical activity into interventions for trauma-exposed individuals, offering a behavioral approach to mitigating stress-related neurobiological changes.

Indexed as

Adverse Childhood ExperiencesAmygdalaExerciseGyrus CinguliHippocampusAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedYoung Adultadverse childhood experiencesamygdalabrain volumehippocampuslimbic systemphysical activity

Identifiers

PMID41111319
PMCPMC12646122

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.