ReviewJournal of obesity & metabolic syndrome2025
Decoding the Adipocyte Epigenome: Differentiation, Metabolic Memory, and Obesity.
Review in Journal of obesity & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Epigenetic legacies of famine: mechanistic pathways to obesity in modern environments.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Latest Advances in Obesity Treatment by Regulating Adipocyte Thermogenesis.PPAR research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adipocytes play a central role in energy balance by integrating lipid storage, thermogenesis, and endocrine regulation. Their diversity-comprising white, brown, and beige adipocytes-emerges through tightly coordinated transcriptional and epigenetic programs. In addition to transcription factors, epigenetic mechanisms such as DNA methylation and histone modifications mediated by acetyltransferases, methyltransferases, and demethylases shape the chromatin states that govern adipocyte differentiation and function. The concept of metabolic memory refers to the long-lasting imprint that environmental and nutritional cues make on cells and tissues; it can facilitate rapid adaptation to subsequent challenges but also predispose organisms to metabolic dysfunction and related complications. Recent technological advances have revealed that cold exposure and obesity leave epigenomic marks on adipocytes, providing mechanistic insights into how metabolic memory is encoded. This review highlights the fundamental principles of the adipose tissue epigenome, the regulation of adipocyte identity, and how epigenomic memory links environmental history to long-term metabolic health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.