Evidence map›Paper›PMID 41111486›Full record

ArticleMaterials today. Bio2025

Dual ROS/pH-responsive mangiferin-loaded smart microneedles for precision therapy of wound infections.

Zhaoping Diao, Jiajun Long, Yang Feng, Guoqing Zhang, Ganghua Yang, Jianqiu Yang, Wenbing Wan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhaoping DiaoDepartment of Orthopaedic Surgery, Institute of Orthopedics of Jiangxi Province and Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Jiajun LongDepartment of Orthopaedic Surgery, Institute of Orthopedics of Jiangxi Province and Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Yang FengDepartment of Orthopaedic Surgery, Institute of Orthopedics of Jiangxi Province and Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Guoqing ZhangDepartment of Orthopaedic Surgery, Institute of Orthopedics of Jiangxi Province and Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Ganghua YangDepartment of Orthopaedic Surgery, Institute of Orthopedics of Jiangxi Province and Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Jianqiu YangDepartment of Orthopaedic Surgery, Institute of Orthopedics of Jiangxi Province and Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Wenbing WanDepartment of Orthopaedic Surgery, Institute of Orthopedics of Jiangxi Province and Jiangxi Provincial Key Laboratory of Spine and Spinal Cord Disease, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infected wound healing remains critically challenged by persistent bacterial biofilms and dysregulated inflammation, whereas conventional silver dressings lack dynamic microenvironment responsiveness and fail to synergize antibacterial efficacy with tissue regeneration. Although conventional silver dressings offer proven antibacterial efficacy, their static nature limits dynamic microenvironment adaptation and synergistic tissue regeneration. To resolve these limitations, we developed an intelligent microneedle patch (PCMA MN) integrating a pH/reactive oxygen species (ROS)-dual-responsive hydrogel matrix composed of gallic acid-grafted chitosan (CG) and TSPBA-crosslinked polyvinyl alcohol (PT) for on-demand drug release, mangiferin (MF)-loaded PLGA microspheres for promoting angiogenesis, and a synergistic silver-gallic acid antibacterial coating. PCMA MNs demonstrated bactericidal capacity comparable to silver dressings, while significantly accelerating wound closure by 14.25 %. This regenerative improvement was driven by enhanced angiogenesis and dynamic macrophage polarization toward regenerative M2 phenotypes, which collectively resolved inflammation and facilitated collagen deposition. Our bioresponsive platform establishes a novel strategy coordinating real-time pharmacokinetics with pro-regenerative immunomodulation, offering transformative potential for complex wound management.

Indexed as

AngiogenesisAntibacterial coatingIntelligent microneedleMacrophage polarizationWound infection

Identifiers

PMID41111486
PMCPMC12528876

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.