ArticleFrontiers in pharmacology2025
Genetic and serum biomarkers of NSAID hypersensitivity reactions.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hypersensitivity reactions (HRs) to non-steroidal anti-inflammatory drugs (NSAIDs) constitute a significant clinical concern due to their frequency and possible severity. These reactions may involve specific immunological pathways, including activation of the high-affinity IgE receptor, or non-immunological mechanisms that result in similar clinical manifestations. Additionally, vitamin D plays an important role in the regulation of the immune response and therefore may be relevant to the development or progression of HRs to NSAIDs. Methods: To identify new single nucleotide variants (SNVs) associated with HRs, we analyzed the exonic regions and the 3'UTR of sixteen genes related to the vitamin D pathway and the high-affinity IgE receptor, namely, Results: We identified 216 variants located in the exonic and 3'regions of these genes, 186 of which were novel. Multinomial analyses identified associations between patients with single NSAID induced urticaria/angioedema or anaphylaxis (SNIUAA) and SNVs in genes related to vitamin D ( Conclusion: Our study highlights a significant association between SNVs in genes related to the vitamin D pathway, retinoid receptors and the high-affinity IgE receptor with the risk of NSAIDs HRs. Additionally, the correlation between IgE levels and clinical phenotypes suggests a potential role for this biomarker in the pathophysiology and stratification of these reactions.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.