Evidence mapPaperPMID 41111526Full record

ReviewFrontiers in pharmacology2025

Management of diabetic foot ulcers: polyherbal formulations and novel delivery systems for herbal active components.

Bowen Feng, Jinjin Dou, Yongji Li, Yihan Wang, Changmei Wu, Xiaodong Lan, Yi Su, Xiwu Zhang

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bowen FengGraduate School, Heilongjiang University of Chinese Medicine, Harbin, China.
Jinjin DouThe Four Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.
Yongji LiGraduate School, Heilongjiang University of Chinese Medicine, Harbin, China.
Yihan WangGraduate School, Heilongjiang University of Chinese Medicine, Harbin, China.
Changmei WuGraduate School, Heilongjiang University of Chinese Medicine, Harbin, China.
Xiaodong LanGraduate School, Heilongjiang University of Chinese Medicine, Harbin, China.
Yi SuGraduate School, Heilongjiang University of Chinese Medicine, Harbin, China.
Xiwu ZhangGraduate School, Heilongjiang University of Chinese Medicine, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic foot ulcers (DFUs) represent devastating complications associated with high risks of amputation and mortality. The complex pathophysiology of the wound microenvironment and systemic involvement render conventional therapies costly and limited in effectiveness. Consequently, there is an urgent demand for the development of effective and comprehensive therapeutic and management strategies. Herbal medicines and their formulations can transform DFU management from passive debridement to active regeneration through multi-target synergy and holistic intervention, offering low-cost and safe alternatives. Integrating herbal active components with polymeric materials enables the development of novel delivery systems and tissue-engineered scaffolds. This interdisciplinary approach is emerging as a promising therapeutic strategy in regenerative medicine and dermal engineering. This paper compares cellular healing mechanisms in DFUs and normal wounds, elucidates the mechanisms of action of herbal medicines and their formulations in treating DFUs, and synthesizes the applications of novel delivery systems for herbal active components in DFU therapy.

Indexed as

diabetic foot ulcersherbal active componentsherbal medicinesnovel drug delivery systemspolyherbal formulationsregenerative medicine

Identifiers

PMID41111526
PMCPMC12531159

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.