Utilizing Circulating MicroRNAs for Personalized Exercise Programs: Insights into Physiological Adaptations and Individual Responses.

Evidence Acquisition: This narrative review included articles sourced from databases such as PubMed, Google Scholar, ScienceDirect, Web of Science, and Scopus, without time limitations. Studies on c-miRNAs related to exercise were reviewed, and the search strategy involved using keywords such as "microRNA," "exercise," and "biomarkers." The selected studies were reviewed based on their relevance to exercise-related c-miRNAs and their contributions to the field. Results: The review identifies multiple c-miRNAs that are sensitive to exercise-induced changes, with miR-1, miR-126, miR-21, and miR-146a showing significant correlations with cardiovascular and muscle adaptations. These findings suggest that c-miRNAs may serve as reliable indicators for individualized training programs, highlighting the importance of molecular responses in tailoring exercise regimens to optimize performance and health outcomes. Conclusions: c-miRNAs offer promising potential for personalized exercise prescriptions. Future studies should aim to elucidate the full regulatory networks and assess the variability of these biomarkers across diverse populations and exercise modalities. Clinicians and sports practitioners can apply this knowledge to refine training strategies, improving athletic performance and health monitoring.