ReviewJournal of cancer prevention2025
Comparative Analysis of Aging-related Metabolic and Biological Markers between Cancer Survivors and Healthy Populations: A Systematic Review.
Review in Journal of cancer prevention, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer survivors may exhibit biological and metabolic changes linked to both cancer and its treatment. This systematic review aimed to compare metabolic and biological aging-related biomarkers between cancer survivors and healthy individuals. The primary electronic databases utilized to search papers from 2019 to 2024 were PubMed, Scopus, and Web of Science. Boolean operators were combined with specific keywords and MESH terms in searching the articles. After excluding protocol papers, studies with incorrect designs or populations, and animal studies, 27 articles were selected for data extraction, synthesis, and quality evaluation. The articles were checked for quality by using the National Institutes of Health (NIH) checklist for observational cohort and cross-sectional studies. Cancer survivors had significant differences in aging-related metabolic and biological biomarkers compared to a healthy population. These include aberrant DNA methylation (hypermethylation, hypomethylation, and epigenetic modification), abnormal expression levels of lipid profiles (high-density lipoprotein, low-density lipoprotein level, malondialdehyde, and apolipoprotein C-1), inflammatory markers (interleukins, C-reactive protein, and TNF-α), immune-senescence (Cellular Communication Network Factor 3 protein), energy regulation (leptin, adiponectin, and mitochondria function profiles), and poor oral and bone health. These findings reflect the accelerated biological age and increased vulnerability to age-related diseases among cancer survivors, as compared to healthy populations. However, considering the cross-sectional design limitations, causal relationships between cancer diagnosis and alterations in biological aging cannot be confirmed. To establish whether cancer itself contributes to accelerated aging, future longitudinal studies are needed that assess metabolic and biological biomarkers in individuals from the time of diagnosis onward.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.