SynthesisFrontiers in nutrition2025
Effects of probiotic supplementation on islet β-cell function in subjects with glucose metabolism disorders: a meta-analysis.
Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Background: Islet β-cell dysfunction is central to the pathophysiology of glucose metabolism disorders. Probiotic supplementation has been shown to benefit glycemic control, but existing evidence on β-cell function remains inconclusive. This meta-analysis investigated the effects of probiotic supplementation on pancreatic islet β-cell function, as assessed by the homeostasis model assessment for β-cell function (HOMA-β), in individuals with impaired glucose metabolism. Methods: A systematic search of PubMed, Embase, Web of Science, and the Cochrane Library was conducted. We included randomized controlled trials (RCTs) comparing probiotics with placebo or no additional treatment in adults with abnormal glucose metabolism. Random-effects meta-analysis was performed, accounting for the potential influence of heterogeneity. Results: Twelve RCTs involving 907 participants were included. Compared with controls, probiotic supplementation significantly improved HOMA-β (mean difference [MD]: 3.04, 95% CI: 0.23 to 5.86; Conclusion: Probiotics might enhance islet β-cell function in individuals with glucose metabolism disorders, particularly among those with elevated baseline HbA1c levels. However, large-scale high-quality RCTs are needed to validate our findings. Systematic review registration: The protocol of the meta-analysis was registered at PROSPERO with the identifier CRD420251087101.
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