Evidence map›Paper›PMID 41112798›Full record

ArticleBiomedical optics express2025

Evaluation of radio frequency ablation in human left atrial tissues for atrial fibrillation using optical coherence tomography.

Ebenezer Raj Selvaraj Mercyshalinie, Dylan O Patterson, Bornface M Mutembei, Avery D Ladymon, Feng Yan, Kaustubh Pandit, Hayden Peek, Kar-Ming A Fung, Qinghao Zhang, Chen Wang and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ebenezer Raj Selvaraj MercyshaliniePeggy and Charles Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, 73019, USA.ORCID https://orcid.org/0000-0003-0648-9428
Dylan O PattersonSchool of Biological Sciences, University of Oklahoma, Norman, OK, 73071, USA.
Bornface M MutembeiPeggy and Charles Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, 73019, USA.ORCID https://orcid.org/0000-0002-6775-9228
Avery D LadymonAerospace and Mechanical Engineering, University of Oklahoma, Norman, OK, 73071, USA.
Feng YanPeggy and Charles Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, 73019, USA.ORCID https://orcid.org/0000-0001-9926-7554
Kaustubh PanditAerospace and Mechanical Engineering, University of Oklahoma, Norman, OK, 73071, USA.ORCID https://orcid.org/0009-0005-9656-4058
Hayden PeekPeggy and Charles Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, 73019, USA.
Kar-Ming A FungDepartment of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73117, USA.
Qinghao ZhangPeggy and Charles Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, 73019, USA.ORCID https://orcid.org/0009-0005-2906-6315
Chen WangPeggy and Charles Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, 73019, USA.ORCID https://orcid.org/0000-0003-4645-3227
Yan CuiPeggy and Charles Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, 73019, USA.
Junyuan LiuPeggy and Charles Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, 73019, USA.
Ronghao LiuPeggy and Charles Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, 73019, USA.
Paulo MartinsDepartment of Surgery, Transplant Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73117, USA.
Stavros StavrakisDepartment of Internal Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK, 73117, USA.
Ke ZhangPeggy and Charles Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, 73019, USA.ORCID https://orcid.org/0000-0003-3194-2546
David R MillerPeggy and Charles Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, 73019, USA.
Qinggong TangPeggy and Charles Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, 73019, USA.ORCID https://orcid.org/0000-0001-9499-5384

Funding

Tissue Pathology Shared ResourceP30CA225520 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ROBERT S. MANNEL · 2018 to 2026
$27.1M
TUMOR RESISTANCE MECHANISMS TO ANTI-VEGF THERAPY IN PROSTATE CANCER (Sukyung Woo)P20GM103639 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI DHANASEKARAN, DANNY N. · 2012 to 2022
$21.3M
Use of 3D Quantitative Optical Methods to Optimize Mebendazole Treatment of Ovarian CancerP20GM135009 · NIGMS · UNIVERSITY OF OKLAHOMA · PI Javier Antonio Jo · 2022 to 2026
$13.6M
Automatic Wide-Field Optical Coherence Tomography for Assessment of Transplant Kidney ViabilityR01DK133717 · NIDDK · UNIVERSITY OF MASSACHUSETTS AMHERST · PI POTTER, STEVEN, TANG, QINGGONG · 2022 to 2025
$2.5M
NCI NIH HHS P30 CA225520NIDDK NIH HHS R01 DK133717NIGMS NIH HHS P20 GM103639NIGMS NIH HHS P20 GM135009
6 · The paper itself

Abstract

Despite its widespread adoption, the success of radiofrequency (RF) ablation is often limited by challenges in achieving durable, transmural lesions while avoiding complications such as incomplete ablation or over-ablation. Optical coherence tomography (OCT) offers high-resolution visualization of cardiac tissue, enabling real-time assessment of lesion depth. Therefore, we investigated the impact of RF ablation on donated human left atrial tissue using an OCT imaging system to assess lesion formation in a controlled laboratory setting. RF ablation lesions were created at durations of 20, 40, 60, 80, and 100 seconds (s), and their effects were quantified by calculating the attenuation coefficient from OCT images. To identify tissue regions in the image, a U-Net model was employed for segmentation, achieving a mean intersection over union (IoU) of 0.9748 with an inference time of 82 milliseconds. Our results demonstrated clear differences in tissue response before and after ablation, with distinct lesion characteristics across the tested durations. One-way ANOVA analysis yielded a p-value of 1.09 × 10

Identifiers

PMID41112798
PMCPMC12532330

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.