ArticleAmerican journal of translational research2025
Correlation between serum 25(OH)D levels and diabetic foot ulcers in elderly patients with type 2 diabetes mellitus.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Vitamin D supplementation and selected metabolic parameters in patients with type 2 diabetes and obesity: a prospective observational study.Frontiers in endocrinology · 2025Observational
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Abstract
objectiveTo explore the correlation between serum 25-hydroxyvitamin D (25(OH)D) levels and diabetic foot ulcers (DFU) in elderly type 2 diabetes mellitus (T2DM) patients.
methodsData of 198 T2DM patients treated at Shanghai Traditional Chinese Medicine-Integrated Hospital from June 2021 to June 2023 were retrospectively analysed. Totally 80 patients with DFU were classified into the study group, while the other 118 were the control group. Outcome measures included serum 25(OH)D levels and nutritional status, the relationship between the severity of DFU and serum 25(OH)D levels, lipid-related and glucose-related indicators, and independent influencing factors for the severity of DFU in elderly T2DM patients.
resultsThe control group demonstrated significantly higher serum 25(OH)D levels compared to the study group (P<0.001), and a lower prevalence of 25(OH)D deficiency (65.25% vs. 86.25%, P=0.001). A strong inverse correlation was observed between Wagner grade and 25(OH)D levels (r=-0.746, P<0.001). The control group presented notably lower total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) levels than the study group (P<0.001), but a notably higher high-density lipoprotein cholesterol (HDL-C) (P<0.001). Multivariate logistic regression analysis identified diabetes duration (OR: 1.15-9.23, P=0.026) and serum 25(OH)D levels (OR: 0.40-0.85, P=0.005) as independent predictors of DFU severity.
conclusion25(OH)D deficiency is strongly associated with the risk of DFU. Diabetes duration and serum 25(OH)D levels are independent risk factors for DFU severity in elderly patients with T2DM.
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