ReviewFood science and biotechnology2025
Dietary sphingolipids and milk fat globule membrane: emerging roles in cardiometabolic health and muscle function.
Review in Food science and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Dietary milk polar lipids ameliorate hepatic lipid accumulation through coordinated regulation of Wnt-PPARγ signaling and remodeling of the gut microbiota.Food science of animal resources · 2026Article
- Metabolites associated with the inclusion of atlantic GRO® seaweed supplementation as a methane mitigation strategy in the diet of replacement beef heifers.Frontiers in molecular biosciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sphingolipids (SPLs) are bioactive lipids that play a critical role in metabolic health. Milk fat globule membrane (MFGM) is a rich source of SPLs, and emerging evidence suggests that dietary SPLs and MFGM contribute to cardiometabolic health. Dietary SPLs, including MFGM, have been shown to reduce intestinal lipid absorption, improve hepatic lipid metabolism, and modulate cholesterol transport. The ceramide (Cer)/sphingosine-1-phosphate (S1P) ratio, rather than total plasma Cer levels, appears to be a key determinant of their effects on insulin resistance, atherosclerosis. myogenesis, and neuromuscular function. Although dietary SPLs, particularly MFGM-derived lipids, offer promising cardiometabolic and muscle health benefits, variations in SPL source, structure, acyl chain length, and phosphorylation state influence their effects. Further research is needed to elucidate the molecular mechanisms, optimize dosage, and establish long-term efficacy.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.