ReviewWorld journal of diabetes2025
Role of astrocytes in diabetic neuropathy: Review of their involvement in disease mechanisms.
Review in World journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Glucagon-Like Peptide-1 Signaling in Learning and Memory: Evidence, Mechanisms, and Therapeutic Implications.Biological psychiatry · 2026Review
- Extrinsic Regulation of Optic Nerve Axon Regeneration in the Adult Central Nervous System.Cells · 2026Review
- A Protective Role of Hydrogen Sulfide Donor GYY4137 Through Activated Microglia-induced Anti-inflammatory Cytokines in the Spinal Cord of Diabetic Rats.Molecular neurobiology · 2026Article
- Astrocytes in Neuropathic Pain: Mechanistic and Global Insights.Pain research & management · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus (DM) and its complications continue to impose a substantial burden on healthcare systems worldwide. Diabetic neuropathy (DN) is one of the most common chronic microvascular and neurodegenerative complications of DM. It is clinically characterized by allodynia, hyperalgesia, and abnormal or absent nerve fiber sensation, which collectively contribute to poor quality of life, sleep disturbances, depression, and increased mortality. Although several pharmacological agents are available to alleviate DN-related symptoms, their limited long-term efficacy and adverse side effects underscore the urgent need for novel therapeutic approaches. This limitation may be attributed to an incomplete understanding of the underlying mechanisms of DN. Accumulating evidence has highlighted the contribution of glial cells including astrocytes, microglia, and oligodendrocytes to the pathogenesis of DN. However, the specific role of astrocytes remains insufficiently defined. Therefore, this review provides a comprehensive evaluation of current knowledge regarding astrocyte involvement in DN mechanisms, with the goal of clarifying their contribution to disease progression and identifying potential therapeutic targets.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.