Evidence map›Paper›PMID 41113496›Full record

ReviewWorld journal of diabetes2025

Exosomes from adipose-derived stem cells: A potential therapeutic strategy for diabetic foot ulcers.

Jia-Xin Mao, Si Chen, Jia-Cheng Li, Han Wang, Mu-Xin Zhao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jia-Xin MaoDepartment of Plastic and Reconstructive Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116000, Liaoning Province, China.
Si ChenDepartment of Plastic and Reconstructive Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116000, Liaoning Province, China.
Jia-Cheng LiDepartment of Plastic and Reconstructive Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116000, Liaoning Province, China.
Han WangDepartment of Vascular Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116000, Liaoning Province, China.
Mu-Xin ZhaoDepartment of Plastic and Reconstructive Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116000, Liaoning Province, China. zhaomuxin@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic foot ulcers are among the most severe complications of the lower limb in patients with diabetes. As the immune resistance decreases due to the long-term exposure to hyperglycemic microenvironment, the wound often fails to heal, leading to a poor prognosis. Foot ulcers have a high risk of amputation and mortality rates making it a growing health concern. Recently, exosomes derived from adipose mesenchymal stem cells have been shown to promote tissue healing, making them a popular topic in cell-free therapies. This article focuses on the risk factors leading to the development of diabetic foot ulcers and the mechanisms of non-healing with the hope to provide new directions or targets for future diabetic foot ulcer treatment. Additionally, this article clarifies the potential mechanisms of action of exosomes from adipose-derived stem cells in promoting the healing of diabetic foot ulcers and discusses its clinical application and limitations. This review aims to provide effective scientific evidence for research on the mechanism and clinical application of exosomes from adipose-derived stem cells for the treatment of diabetic foot ulcers.

Indexed as

Diabetic foot ulcersDiabetic woundsExosomesHealingMechanism

Identifiers

PMID41113496
PMCPMC12531680

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.