ArticlePostepy w kardiologii interwencyjnej = Advances in interventional cardiology2025
Assessment of cardiac function and left ventricular dyssynchrony in patients with ANCA-associated vasculitis using speckle-tracking echocardiography.
Article in Postepy w kardiologii interwencyjnej = Advances in interventional cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is a systemic autoimmune disease that may cause subclinical cardiac involvement, increasing morbidity and mortality. Aim: This study aimed to evaluate subclinical myocardial dysfunction, including both left ventricular (LV) and right ventricular (RV) function, as well as LV dyssynchrony, in patients with ANCA-associated vasculitis (AAV) using speckle-tracking echocardiography (STE). Material and methods: The study included 39 consecutive patients with AAV (mean age: 52.9 ±12.8 years, 19 male sex) and 44 healthy controls (mean age: 50.2 ±8.7 years, 28 male sex). All participants underwent standard transthoracic echocardiography. LV and RV strain parameters including global longitudinal strain (GLS), as well as LV dyssynchrony assessed by peak systolic dispersion (PSD), were evaluated using STE. Results: LV GLS was significantly reduced in patients with AAV compared to healthy controls (-16.6 ±2.2% vs. -19.6 ±2.0%, Conclusions: STE revealed subclinical impairments in both LV and RV function in patients with AAV, despite normal EF and no overt clinical symptoms, which emphasizes the value of cardiac monitoring to explore cardiac involvement.
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