ArticleOral health & preventive dentistry2025
Lifestyle, Inflammation, and Periodontitis: A National Study Based on the Life's Crucial 9 Framework.
Article in Oral health & preventive dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo examine the association between the Life's Crucial 9 (LC9) lifestyle score and periodontitis severity among U.S. adults, and to explore the mediating roles of systemic inflammation and oxidative stress. The study hypothesis is that higher LC9 scores are associated with lower periodontitis severity. MATERIALS AND
methodsThis cross-sectional study used data from 7124 adults aged ≥30 years from the 2009-2014 National Health and Nutrition Examination Survey (NHANES). Weighted logistic, ordinal logistic, and linear regression models assessed the relationships between LC9 and periodontitis risk, severity, clinical attachment loss (CAL), and probing depth (PD). Restricted cubic spline (RCS) regression examined dose-response trends. Weighted quantile sum (WQS) regression evaluated the relative contribution of LC9 components. Mediation analysis was performed to assess inflammatory and oxidative pathways. Receiver operating characteristic (ROC) analysis compared the predictive performance of LC9 and Life's Essential 8 (LE8).
resultsEach 10-point increase in LC9 was associated with a reduced risk of periodontitis (OR = 0.858, 95% CI: 0.808-0.911), milder severity, and lower CAL and PD. Tobacco exposure and glycemic control were the strongest contributors. White blood cell count, systemic inflammation index (SIRI), and albumin mediated 25.1%, 7.3%, and 5.3% of the LC9-periodontitis relationship, respectively. No statistically significant mediation was observed for oxidative stress. LC9 and LE8 demonstrated comparable predictive performance (AUC: 0.758 vs 0.759).
conclusionHigher LC9 scores were statistically significantly associated with better periodontal outcomes, primarily through inflammatory pathways. Clinically, modifying key lifestyle factors - especially tobacco avoidance and glycemic control - may effectively reduce periodontitis risk.
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