SynthesisJournal of neurology2025
Risks of stroke and myocardial infarction after retinal artery occlusion and their time dependence: a systematic review and meta-analysis.
Synthesis in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Migraine as a risk factor for retinal vascular events and maculopathies: a systematic review and meta-analysis of 47 million individuals.The journal of headache and pain · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundRetinal artery occlusion (RAO) is an ophthalmic emergency that may signal underlying cardiovascular disease. Both stroke and myocardial infarction (MI) share pathophysiological mechanisms and risk factors with RAO. This systematic review aimed to assess the risks of stroke and MI following the onset of RAO, with a focus on their time-dependent changes.
methodsPubMed, Embase, and Web of Science were searched for articles reporting incidence of stroke and MI after RAO. Newcastle-Ottawa Scale was employed to evaluate the quality of study. Pooled relative risks for stroke and MI risks following RAO were calculated by random-effects models, and the time-dependent change of these risks was analyzed.
resultsTwelve studies involving 319 748 people were included. Pooled analysis showed that RAO was associated with a significantly increased risk of stroke (RR = 3.64, 95% CI: 2.53-5.25, p < 0.0001), particularly within the first month after RAO. MI risk showed an upward trend (RR = 1.38, 95% CI: 0.80-2.40, p = 0.2478), but did not reach statistical significance. Time-stratified analyses revealed the highest incidence of stroke and MI within 30 days post-RAO.
conclusionRAO is strongly associated with an elevated short-term risk of stroke, underscoring the need for prompt cerebrovascular evaluation and monitoring within the first month. Although the association between RAO and MI was less conclusive, cardiovascular assessment remains warranted. These findings highlight RAO as an important marker of systemic vascular disease requiring timely intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.